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Accepted for/Published in: JMIRx Med

Date Submitted: Feb 27, 2021
Open Peer Review Period: Feb 27, 2021 - Apr 24, 2021
Date Accepted: Jun 25, 2021
Date Submitted to PubMed: Aug 4, 2023
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Emergence of the First Strains of SARS-CoV-2 Lineage B.1.1.7 in Romania: Genomic Analysis

Lobiuc A, Dimian M, Sturdza O, Filip R, Covasa M

Emergence of the First Strains of SARS-CoV-2 Lineage B.1.1.7 in Romania: Genomic Analysis

JMIRx Med 2021;2(3):e28049

DOI: 10.2196/28049

PMID: 34424256

PMCID: 8363123

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Emergence of first strains of Sars-CoV-2 lineage B.1.1.7 in Romania

  • Andrei Lobiuc; 
  • Mihai Dimian; 
  • Olga Sturdza; 
  • Roxana Filip; 
  • Mihai Covasa

ABSTRACT

United Kingdom reported the emergence of a new and highly transmissible SARS-CoV-2 variant B.1.1.7. that rapidly spread to other contries. The impact of this new mutation that occurs in the S protein, on infectivity, virulence and current vaccine effectiveness is still under evaluation. We have identified the first cases of the B.1.1.7 variant in samples collected from Romanian patients, of which one was traced to the UK region where the new variant was originally sequenced. Mutations in the Nsp3 protein, N844S and D455N and L15F in Orf3a were also detected, indicating common ancestry with UK strains as well as remote connections with strains from Nagasaki, Japan. These results indicate, for the first time, the presence and characteristics of the new variant B.1.1.7 in Romania and underscore the need for increased genomic sequencing in confirmed COVID-19 patients.


 Citation

Please cite as:

Lobiuc A, Dimian M, Sturdza O, Filip R, Covasa M

Emergence of the First Strains of SARS-CoV-2 Lineage B.1.1.7 in Romania: Genomic Analysis

JMIRx Med 2021;2(3):e28049

DOI: 10.2196/28049

PMID: 34424256

PMCID: 8363123

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