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Li Y, Guo Y, Hong Y, Zeng C, Zeng Y, Zhang H, Zhu M, Qiao J, Cai W, Li L, Liu C
Mediating Effects of Stigma and Depressive Symptoms in a Social Media–Based Intervention to Improve Long-term Quality of Life Among People Living With HIV: Secondary Analysis of a Randomized Controlled Trial
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Mechanisms of a Social Media-based Intervention to Improve Long-term QOL among People Living with HIV: Mediating Effects of Stigma and Depressive Symptoms.
Yiran Li;
Yan Guo;
Y.Alicia Hong;
Chengbo Zeng;
Yu Zeng;
Hanxi Zhang;
Mengting Zhu;
Jiaying Qiao;
Weiping Cai;
Linghua Li;
Cong Liu
ABSTRACT
Background:
Mobile health (mHealth) interventions have been shown to effectively improve quality of life (QOL) among people living with HIV (PLWH). However, little is known about the mechanisms of how mHealth interventions take effects, especially in the long term.
Objective:
This study aimed to explore the intervention mechanisms of a social media-based intervention, Run4Love, on QOL over 9-month follow-up.
Methods:
A total of 300 people living with HIV and depressive symptoms were randomized to the intervention group or control group in a 1:1 ratio. The 3-month intervention comprised two components: cognitive-behavioral stress management (CBSM) courses and physical activity promotion. Structural equation model (SEM) with longitudinal data was conducted to examine the sequential mediating effects of HIV-related stigma and depressive symptoms on the long-term intervention effects on QOL.
Results:
Results showed that the intervention had significantly improved QOL at 9 months via complete mediating effects of reduced HIV-related stigma at 3 months and decreased depressive symptoms at 6 months.
Conclusions:
The findings underscore the critical roles of HIV-related stigma and depressive symptoms in an mHealth intervention with long-term effect on QOL improvements. We call for targeted mHealth interventions to improve QOL among PLWH, especially social media-based interventions that can address HIV-related stigma and alleviate depressive symptoms. Clinical Trial: The trail was registered in the Chinese Clinical Trial Registry (ChiCTR-IPR-17012606).
Citation
Please cite as:
Li Y, Guo Y, Hong Y, Zeng C, Zeng Y, Zhang H, Zhu M, Qiao J, Cai W, Li L, Liu C
Mediating Effects of Stigma and Depressive Symptoms in a Social Media–Based Intervention to Improve Long-term Quality of Life Among People Living With HIV: Secondary Analysis of a Randomized Controlled Trial