JMIR Publications

ABSTRACT

Background:

In breast cancer (BCa) survivors, chemotherapy induced muscle loss has been shown to be reserved with structured resistance exercise. Creatine supplementation can increase bioenergetics in skeletal muscle, helping improve overall strength and endurance. Therefore, we hypothesize that adding creatine supplementation can accelerate exercise adaptations in BCa survivors. Methods/Design: We aim to test this hypothesis by conducting an open-label, randomized controlled trial of 30 BCa survivors that have completed chemotherapy within 6 months of enrollment. Eligible participants will be equally randomized (1:1) to either a creatine + exercise group or an exercise only group for this 12-week intervention. Individuals randomized to receive creatine will be initially dosed at 20 g/day for 7 days to boost availability of creatine systemically. Thereafter, the dose will be reduced to 5 g/day for maintenance through the duration of the 12-week protocol. All participants will engage in three center-based exercise sessions completing 3 sets of 8-12 repetitions on the chest press, leg press, seated row, shoulder press, leg extension and leg curl machines. Primary outcomes include changes in strength, body composition, and physical function in BCa survivors. Secondary outcomes are intramuscular concentrations of creatine and ATP in the vastus lateralis, mid-thigh cross sectional area and quality of life. Discussion: Creatine is being studied as a potential agent to improve adaptations to exercise in BCa survivors following chemotherapy. Findings from this trial may have future implications to supporting BCa survivors reverse the muscle loss experienced during chemotherapy and improve their physical function and quality of life.