Accepted for/Published in: Journal of Medical Internet Research
Date Submitted: Oct 13, 2020
Date Accepted: Mar 16, 2021
Sweet Pregnancy 4.0 – Systematic Review on Clinical Effectiveness of different Diabetes-Technologies in Diabetic Pregnancies
ABSTRACT
Background:
Hyperglycemia in Pregnancy (HIP) occurs worldwide and is closely associated with health issues in women and their offspring, such as pregnancy and birth complications respectively comorbidities, as well as metabolic and cardiovascular diseases. To optimize the management of diabetic pregnancies, sustainable strategies are urgently needed. Analyzes of the constantly evolving diabetes technologies, which can help to manage pregnancy and health, are much required.
Objective:
A systematic review to assess the clinical effectiveness of diabetes technologies in diabetic pregnancies by analyzing glycemic control, pregnancy and birth related outcomes, and neonatal outcomes.
Methods:
Relevant databases including MEDLINE (PubMed), Cochrane Library, EMBASE, CINAHL and Web of Science Core Collection were searched in September 2020 for clinical studies (2008-2020). Findings were organized by type of diabetes (1), type of technology (2) and outcomes(3).
Results:
We identified n=15 randomized controlled trials (RCT), n=3 randomized crossover trials (RcrT), n=2 cohort studies, and n=2 controlled clinical trials (CCT). Overall, n=9 studies focused on T1DM, n=10 on GDM and n=3 on T1DM and T2DM. We assessed n=9 studies with strong, n=11 with moderate, and n=2 with weak quality. Diabetes technologies seem to have a particularly positive effect on glycemic control in all types of diabetes, as shown by some studies of strong and moderate quality. Positive trends in pregnancy, birth related and neontal outcomes were observed.
Conclusions:
Diabetes technologies have the potential to effectively improve the management of diabetic pregnancies. Further research is needed on the clinical effectiveness of diabetes technologies in pregnant women, especially for T2DM. Clinical Trial: N/A
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