Accepted for/Published in: JMIR Research Protocols
Date Submitted: Aug 27, 2020
Date Accepted: Apr 7, 2021
Investigating Exhaled Breath Condensate Hydrogen Peroxide levels and other exhaled breath condensate parameters, as measured by Inflammacheck™ in health and respiratory disease (The VICTORY Study): Protocol for a cross-sectional, observational study
ABSTRACT
Background:
More than 7% of the world’s population are living with a chronic respiratory condition. In the UK, lung disease affects approximately 1 in 5 people, leading to over 700,000 hospital admissions each year. People with respiratory conditions can suffer significantly with their symptoms and can require multiple healthcare visits and investigations before a diagnosis is made. The tests available can be difficult to perform, especially if the person is symptomatic, leading to poor quality results. A new, easy to perform, point of care test that could be performed in any healthcare setting, and that can differentiate between various respiratory conditions would have a significant beneficial impact on our ability to diagnose respiratory disease.
Objective:
The objective of this study is to use a new handheld device (the Inflammacheck™) in different respiratory conditions to measure the exhaled breath condensate hydrogen peroxide (EBC H2O2) and compare these results with healthy controls. We will also aim to determine whether the device can measure other parameters including breath humidity, breath temperature, breath flow dynamics and end tidal carbon dioxide.
Methods:
We will perform a single visit, cross-sectional, observational study of EBC H2O2 levels, as measured by Inflammacheck™ in people with respiratory disease and volunteers with no known lung disease. Participants with a confirmed diagnosis of asthma, chronic obstructive pulmonary disease (COPD), lung cancer, bronchiectasis, pneumonia, breathing pattern disorder (BPD) and interstitial lung disease (ILD), as well as volunteers with no history of lung disease will be asked to breathe into the Inflammacheck™ device to record their breath sample.
Results:
The results from the study will be available in 2022 in anticipation of COVID-19 related delays.
Conclusions:
This study will investigate the EBC H2O2 as well as other exhaled breath parameters for use as a future diagnostic tool.
Citation
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Copyright
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