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Borobia A, García-García I, Díaz-García L, Rodríguez-Mariblanca A, Martínez de Soto L, Monserrat Villatoro J, Seco Meseguer E, González JJ, Frías Iniesta J, Ramírez García E, Arribas JR, Carcas-Sansuán AJ
Health Care Workers’ Reasons for Choosing Between Two Different COVID-19 Prophylaxis Trials in an Acute Pandemic Context: Single-Center Questionnaire Study
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Healthcare workers’ reasons for choosing between two different COVID-19 prophylaxis trials in an acute pandemic context: Results from an online survey
Alberto Borobia;
Irene García-García;
Lucía Díaz-García;
Amelia Rodríguez-Mariblanca;
Lucía Martínez de Soto;
Jaime Monserrat Villatoro;
Enrique Seco Meseguer;
Juan J. González;
Jesús Frías Iniesta;
Elena Ramírez García;
Jose Ramón Arribas;
Antonio J Carcas-Sansuán
ABSTRACT
Background:
In April 2020, two independent clinical trials (CT) to assess SARS-Cov-2 prophylaxis in healthcare workers were started in our Hospital: MeCOVID (melatonin vs placebo) and EPICOS (tenofovir disoproxil/emtricitabine vs hydroxychloroquine vs the combination of both vs placebo).
Objective:
We aim to evaluate the motivations to participate and the reasons to choose one or another.
Methods:
Both CTs were offered to personnel through the internal news bulletin. After the screening visit, all subjects were asked to answer a web-based survey.
Results:
In the first month, 206 healthcare workers were screened and 160 randomized. Survey participation was quite high, 73.3%. The main motivation to participate was “to contribute to scientific knowledge” 53.0%, followed by “to avoid SARS-Cov-2 infection” and “the interest to be tested for SARS-CoV-2”. We found differences between physicians and nurses in the expected personal benefits (P<0.05). The vast majority of the volunteers selected the MeCOVID study, the main reason was the fear of adverse reactions associated with treatments in EPICOS, 69.4%.
Conclusions:
Healthcare workers´ motivations to participate in prophylaxis trials in a pandemic context appear to be driven mostly by their desire to contribute to science and getting some health benefits. Safety seems to weight way more than efficacy to choose between CTs.
Citation
Please cite as:
Borobia A, García-García I, Díaz-García L, Rodríguez-Mariblanca A, Martínez de Soto L, Monserrat Villatoro J, Seco Meseguer E, González JJ, Frías Iniesta J, Ramírez García E, Arribas JR, Carcas-Sansuán AJ
Health Care Workers’ Reasons for Choosing Between Two Different COVID-19 Prophylaxis Trials in an Acute Pandemic Context: Single-Center Questionnaire Study