Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.
Who will be affected?
Readers: No access to all 28 journals. We recommend accessing our articles via PubMed Central
Authors: No access to the submission form or your user account.
Reviewers: No access to your user account. Please download manuscripts you are reviewing for offline reading before Wednesday, July 01, 2020 at 7:00 PM.
Editors: No access to your user account to assign reviewers or make decisions.
Copyeditors: No access to user account. Please download manuscripts you are copyediting before Wednesday, July 01, 2020 at 7:00 PM.
Pluimakers V, Fiocco M, Van Atteveld J, Hobbelink M, Bresters D, Van Dulmen-den Broeder E, Van der Heiden-van der Loo M, Janssens G, Kremer L, Loonen J, Louwerens M, Van der Pal H, Ronckers C, Van Santen H, Versluijs B, De Vries A, Van den Heuvel-Eibrink M, Neggers S
Metabolic Syndrome Parameters, Determinants, and Biomarkers in Adult Survivors of Childhood Cancer: Protocol for the Dutch Childhood Cancer Survivor Study on Metabolic Syndrome (Dutch LATER METS)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Metabolic syndrome parameters, determinants, and biomarkers in adult survivors of childhood cancer: methodology of the Dutch Childhood Cancer Survivor Study Metabolic Syndrome (Dutch LATER METS Study)
Vincent Pluimakers;
Marta Fiocco;
Jenneke Van Atteveld;
Monique Hobbelink;
Dorine Bresters;
Eline Van Dulmen-den Broeder;
Margriet Van der Heiden-van der Loo;
Geert Janssens;
Leontien Kremer;
Jacqueline Loonen;
Marloes Louwerens;
Heleen Van der Pal;
Ceciel Ronckers;
Hanneke Van Santen;
Birgitta Versluijs;
Andrica De Vries;
Marry Van den Heuvel-Eibrink;
Sebastian Neggers
ABSTRACT
Background:
Potential long-term effects of treatment for childhood cancer include adiposity, insulin resistance, dyslipidemia and hypertension. These risk factors cluster together as metabolic syndrome (MetS) and increase the risk for development of diabetes mellitus and cardio- and cerebrovascular disease. Knowledge on risk factors, timely diagnosis and preventive strategies is of importance to prevent cardio- and cerebrovascular complications and improve quality of life. Currently, no studies in national cohorts on prevalence and determinants of MetS in childhood cancer survivors including biomarkers and genetic predisposition are available.
Objective:
Describe the methodology of the Dutch LATER METS study on prevalence and risk factors of metabolic syndrome in adult survivors of childhood cancer, treated between 1963 and 2002.
Methods:
The current study is a cross-sectional study, based on recruitment of a national cohort of adult long-term survivors, that will assess 1) prevalence as well as disease- and treatment-related and genetic risk factors of MetS and its separate components, compared to available normative data, and 2) diagnostic value of biomarkers. Metabolic syndrome will be classified according to the definitions of the National Cholesterol Education Program (NCEP-ATPIII) as well as the International Diabetes Federation (IDF), and DXA-scans will be performed to assess body composition in more detail. A total of 2380 survivors was included, between 2016 and 2020, in seven pediatric oncology hospitals.
Results:
n.a.
Conclusions:
The Dutch LATER METS study will provide knowledge on clinical and genetic determinants of MetS, and the diagnostic value of biomarkers, in survivors. The results of this study will be used to optimize surveillance guidelines for MetS in survivors, and improve follow-up of survivors.
Citation
Please cite as:
Pluimakers V, Fiocco M, Van Atteveld J, Hobbelink M, Bresters D, Van Dulmen-den Broeder E, Van der Heiden-van der Loo M, Janssens G, Kremer L, Loonen J, Louwerens M, Van der Pal H, Ronckers C, Van Santen H, Versluijs B, De Vries A, Van den Heuvel-Eibrink M, Neggers S
Metabolic Syndrome Parameters, Determinants, and Biomarkers in Adult Survivors of Childhood Cancer: Protocol for the Dutch Childhood Cancer Survivor Study on Metabolic Syndrome (Dutch LATER METS)