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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: May 24, 2020
Date Accepted: Jul 26, 2020

The final, peer-reviewed published version of this preprint can be found here:

Real-World Evidence on the Effect of Missing an Oral Contraceptive Dose: Analysis of Internet Search Engine Queries

Hochberg I, Orshalimy S, Yom-Tov E

Real-World Evidence on the Effect of Missing an Oral Contraceptive Dose: Analysis of Internet Search Engine Queries

J Med Internet Res 2020;22(9):e20632

DOI: 10.2196/20632

PMID: 32930672

PMCID: 7525397

Real-world evidence on the effect of missing a dose of oral contraceptive: An examination of internet search engine queries

  • Irit Hochberg; 
  • Sharon Orshalimy; 
  • Elad Yom-Tov

ABSTRACT

Background:

Oral Contraceptives (OCs) are a unique chronic medication where a slip of memory may be experienced as a threat that could change the life course of a person. Subjective concerns in women missing doses of OCs have been addressed infrequently. Anonymized queries to internet search engines provide a unique access to concerns and information gaps in a large number of internet users.

Objective:

We sought to quantitate the frequency of queries by women seeking information in an internet search engine after missing one or more doses of an OC, their further queries on emergency contraception, abortion and miscarriage and their rate of reporting a pregnancy timed to the cycle of missing an OC.

Methods:

We extracted all English-language queries submitted to Bing in the US during 2018 which mentioned a missed OC, and subsequent queries of the same users on miscarriage, abortion, emergency contraceptives and week of pregnancy.

Results:

We identified 26,395 Bing users in the US who queried on missing OC pills and the fraction who further queried about miscarriage, abortion, emergency contraceptive and week of pregnancy. Users under the age of 30 who asked about forgetting an OC dose were more likely to ask about abortion (x 1.5) and emergency contraception (x 1.7) (p-value=0.00006 and 0.00001, respectively), while at ages 30-34 queries about pregnancy (x 2.1) and miscarriage (x 5.4) were more likely (p-value= 0.000002 and 0.000004, respectively).

Conclusions:

Our data indicate that many women missing a dose of OC might not have received sufficient information from their healthcare providers or chose to obtain it online. Queries about abortion and miscarriage peaking in subsequent days indicate a common worry of possible pregnancy. These results reinforce the importance of providing comprehensive written information on missed pills when prescribing an OC.


 Citation

Please cite as:

Hochberg I, Orshalimy S, Yom-Tov E

Real-World Evidence on the Effect of Missing an Oral Contraceptive Dose: Analysis of Internet Search Engine Queries

J Med Internet Res 2020;22(9):e20632

DOI: 10.2196/20632

PMID: 32930672

PMCID: 7525397

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