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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: May 4, 2020
Date Accepted: Jun 3, 2020
Date Submitted to PubMed: Jun 4, 2020

The final, peer-reviewed published version of this preprint can be found here:

Epidemiological Observations on the Association Between Anosmia and COVID-19 Infection: Analysis of Data From a Self-Assessment Web Application

Denis F, Galmiche S, Dinh A, Fontanet A, Scherpereel A, Benezit F, Lescure FX

Epidemiological Observations on the Association Between Anosmia and COVID-19 Infection: Analysis of Data From a Self-Assessment Web Application

J Med Internet Res 2020;22(6):e19855

DOI: 10.2196/19855

PMID: 32496206

PMCID: 7295000

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Viewpoint: Epidemiological observation from a smartphone self-assessment web-application for suspected COVID-19 patients’ triage: association of anosmia and outbreak extension in France.

  • Fabrice Denis; 
  • Simon Galmiche; 
  • Aurélien Dinh; 
  • Arnaud Fontanet; 
  • Arnaud Scherpereel; 
  • Francois Benezit; 
  • François-Xavier Lescure

ABSTRACT

We developed a self-assessment web-application for COVID-19 which was launched in France in March 2020. Users were asked questions about underlying conditions, sociodemographic status, Zip code and main COVID-19 symptoms. Depending on symptoms reported and the co-existing disorders, users were offered either to stay at home, or to contact a general practitioner or an emergency phone number. As of March 29, 2020, the application was opened 4 176 314 times, 3 485 218 e-questionnaires were filled, and 2 304 742 users had at least one symptom. 33.9% of patients reported no symptoms. The remaining patients were offered self-monitoring (22.9%), GP visit or teleconsultation (27.7%), and emergency call (15.6%). Anosmia was associated with emergency warning signs in 39.0% versus and 22.9% of patients without anosmia. Anosmia, and fever and/or cough were correlated with hospitalizations for Covid-19 (Spearman correlation coefficients = 0.87 and 0.82, respectively; p<0.0001 for both). This study suggests that anosmia may be strongly associated with COVID-19 and its severity. Self-checking application data could be a relevant tool to follow outbreak dynamic.


 Citation

Please cite as:

Denis F, Galmiche S, Dinh A, Fontanet A, Scherpereel A, Benezit F, Lescure FX

Epidemiological Observations on the Association Between Anosmia and COVID-19 Infection: Analysis of Data From a Self-Assessment Web Application

J Med Internet Res 2020;22(6):e19855

DOI: 10.2196/19855

PMID: 32496206

PMCID: 7295000

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