Accepted for/Published in: JMIR Research Protocols
Date Submitted: Apr 8, 2020
Date Accepted: Sep 30, 2020
Biological age model designed for health promotion interventions: From data collection to clincial applicability
ABSTRACT
Background:
Actions to improve healthy aging and delay morbidity has never been more important considering the aging demographics of the world. We propose that estimation of biological age has value in health promotion of the general population. Biological age assesses the heterogeneity in functional status and vulnerability to disease that chronological age fails to do. Thus, biological age assessment is a tool that provides an outcome, which is intuitively meaningful for the general population, and as such, makes it easy to understand to what extent lifestyle can expand health span.
Objective:
The aim of this interdisciplinary study is to develop a biological age model and explore its usefulness.
Methods:
The development of a pilot model comprises three consecutive phases: (1) Conducting a cross-sectional study to gather indicators from 100 individuals representing normal healthy aging (the derivation cohort); (2) estimating biological age by the application of principal component analysis and (3) testing the clinical use of the model in a validation cohort of overweight adults attending a lifestyle intervention course.
Results:
We have completed data collection and the initial results from the principal component analysis are ready. Interpretation and refinement of the model is ongoing. Recruitment to the validation cohort is forthcoming.
Conclusions:
We expect to find that the biological age model is useful as an indicator of risk of disease and metabolic risk, and further research should focus on validating the model on a larger scale. Clinical Trial: Phase 1 study: Clinical Trial number: NCT03680768. Phase 2 study: Clinical Trial number: NCT04279366.
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