Accepted for/Published in: JMIR Research Protocols
Date Submitted: Jul 29, 2019
Open Peer Review Period: Aug 1, 2019 - Sep 26, 2019
Date Accepted: Feb 26, 2020
(closed for review but you can still tweet)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Intravital Microscopy (IVM) in Human Solid Tumors
ABSTRACT
Background:
Intravital microscopy (IVM) allows the real-time, direct visualization of microscopic blood vessels. This clinical study will elucidate the hemodynamic properties of microvessels associated with deep space solid tumors.
Objective:
The main objective of this study is to determine the feasibility of performing HIVM in patients with deep space solid tumors during the standard course of surgical treatment (resection). HIVM observations will also be performed when vasopressors or fluid boluses are administered during the standard course of surgical treatment.
Methods:
This is an open-label, non-randomized, single center, study of IVM observation in subjects with deep space solid tumors undergoing surgical resection and will be performed in the in-patient setting.
Results:
These data will serve as the basis for comparisons of microscopic tumor vessel findings and clinical outcomes.
Conclusions:
This proposed trial will support the development of interventions to improve patient treatment by extending the application of IVM to the tumor microenvironment. Human intravital microscopy (HIVM) observations will be added during the course of volume and pressor management during the course of surgery and may result in data which may offer a means to augment responses to systemic treatments.
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Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.