Accepted for/Published in: JMIR Research Protocols
Date Submitted: May 19, 2019
Open Peer Review Period: May 23, 2019 - Jun 6, 2019
Date Accepted: Jul 28, 2019
(closed for review but you can still tweet)
Protocol for a systematic review and meta-analysis of the influence of ADRB2 genetic polymorphisms on albuterol therapy for patients with asthma
ABSTRACT
Background:
Albuterol is one of the most frequently used medications in clinical practice, and seeing interindividual variabilities of responses to albuterol is not uncommon. Multiple studies have been conducted to investigate the associations of responses due to albuterol particularly with regards to the two non-synonymous single nucleotide polymorphisms (SNPs) at positions 16 (Arg16Gly; rs1042713) and 27 (Glu27Gln; rs1042714) on the adrenoceptor beta 2 (ADRB2) gene. However, the directions of the correlations are conflicting.
Objective:
The objective of this systematic review and meta-analysis is to assess the effect of the two SNPs on the ADRB2 gene in terms of responses presented shortly after albuterol inhalation in patients with asthma.
Methods:
A comprehensive literature review search using the OVID platform, using MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL), will be conducted by a specialized librarian without language restrictions. All abstracts will be reviewed by two authors (KH and SK). The two authors will individually perform data extraction from each eligible study, and any disagreements will be resolved through discussion with a third party (TK). Risk of bias for all included studies will be independently assessed using quality of genetic association studies (Q-Genie) tool. We will report the systematic review and meta-analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A narrative synthesis of study results or meta-analyses will be undertaken when appropriate.
Results:
Status of data analysis is that we have started preliminary searches and are piloting the study selection process. Anticipated completion date is July 30th, 2019.
Conclusions:
Our study will provide a systematic review and meta-analysis on the potential effects of the two non-synonymous SNPs on the ADRB2 gene on responses presented shortly after albuterol inhalation among patients with asthma, which would clarify the current evidence of these associations and, if positive correlations are found, could enhance more personalized pharmacotherapy in albuterol use.
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Copyright
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