JMIR Publications

ABSTRACT

Background:

Despite the positive effect of exercise is quite predictable in hepatocellular carcinoma (HCC) patients, these patients are hesistant to start and build up exercise for one major reason: the vague fear of developing hepatic decompensation, a potentially fatal condition that can even lead to death. Integrating mobile healthcare (mHealth) with individualized exercise program could be a possible option for promoting physical capacity of HCC patients.

Objective:

The aim of this study was to evaluate the efficacy and safety of rehabilitation exercises individually prescribed via an mHealth application on physical fitness, body composition, biochemical profile, and quality of life in HCC patients.

Methods:

A total of 37 HCC patients were enrolled in a 12-week course with an mHealth application program targeted to HCC patients. At baseline, 6-week, and 12-week, participants’ physical fitness levels (6-minute walk test, grip strength test, 30-second chair stand test) were measured. Physical activity level (IPAQ), body composition (BMI, body fat percentage, muscle mass), biochemical profiles, and quality of life (EORTC QLQ-C30) were assessed at baseline and endpoint. At the 6-week midpoint, exercise intensity was individually adjusted.

Results:

Of the 37 patients, 31 completed the 12 weeks of intervention. Grip strength improved significantly after 12 weeks of intervention. The 30-second chair stand test and 6 minute walk test showed significant improvement after 6 and 12 weeks, and from 6 to 12 weeks. Muscle mass and IPAQ score increased significantly after 12 weeks of intervention without biochemical deterioration.

Conclusions:

Twelve weeks of mhealth care, including an individually prescribed rehabilitation exercise program, significantly improved physical fitness, body composition, and physical activity without any complication or biochemical deterioration in compensated HCC patients who had completed therapy.