Previously submitted to: JMIR Mental Health (no longer under consideration since Mar 06, 2019)
Date Submitted: Mar 4, 2019
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Ecological Momentary Assessment of Depressive Symptoms Using the mind.me Application: A Validation Study
Background:
Ecological momentary assessment (EMA) for mental disorders has been insufficiently evaluated and validated with rigorous, adequately-powered, high-quality studies.
Objective:
Herein, we sought to validate the mind.me application (app) for the assessment of depressive symptoms in adults.
Methods:
Adults (ages 18-65) who self-identified as having clinically significant depressive symptoms [i.e. Patient Health Questionnaire 9 (PHQ-9) ≥ 5] utilized the mind.me app—a mobile phone technology that collects data passively and continuously, and is capable of integrating broad multimodal data [e.g., location variance (e.g. GPS), behavioural (e.g. social network activity), and communication data (e.g. SMS texting, phone calls)]. The primary outcome was predictive accuracy (i.e. convergent validity with depressive symptom measurement, as captured by the PHQ-9).
Results:
200 subjects were enrolled in the study (mean age 46 ±12.71). The average PHQ-9 score was 12.8 ±6.9. The predictive accuracy of the mind.me app was 0.91 ±0.06. The sensitivity was 0.98 and the specificity was 0.93. The mind.me app was rated by 200 users as highly usable and informative to their illness.
Conclusions:
The mind.me app exhibits robust predictive accuracy in detecting depressive symptoms in adults with clinically relevant depressive symptoms. The mind.me app is one of the first rigorously validated EMA tools for adults capable of detecting depressive symptoms. Future vistas aim to evaluate mind.me’s capability of impacting healthcare and cost outcomes in individuals with mood disorders. The mind.me app provides a unique opportunity for enhanced assay sensitivity in mood disorder research.
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