Accepted for/Published in: JMIR Research Protocols
Date Submitted: Dec 3, 2018
Date Accepted: Aug 21, 2019
(closed for review but you can still tweet)
Impact of perinatal different intrauterine environments on child growth and development in the first six months of life: Profile of IVAPSA Study.
ABSTRACT
Background:
Several studies have shown that perinatal events may impact on the health outcomes in children and adults.
Objective:
Considering the potential for interventions during pregnancy and first years of life, the IVAPSA study aim to amplify the knowledge upon the impact of different intrauterine environments on infant growth and development.
Methods:
The recruitment 24 to 48 hours after delivery involved mothers and their newborns in two public hospitals from Porto Alegre, Brazil, from December 2011 to January 2016. The pairs were allocated into five groups: DM - participant with clinical diagnosis of diabetes, considering any disease classification; SAH - participant with clinical diagnosis of hypertensive disease during pregnancy; MS - participant who smoked at any moment of gestation; SGA - participant with newborn small for gestational age; and CTL - participant without the clinical characteristics previously mentioned. Several protocols were applied in interviews that were conducted at postpartum, 7 and 15 days and at 1, 3 and 6 months of the infant's life. For this work, we analyzed only data collected during postpartum interview. The statistical analyses were performed using Pearson chi-square test, Mann Whitney test, or Kruskal Wallis test with Dunn post-hoc. The significance level was set at 5%.
Results:
Of the 485 eligible mother-newborn pairs, only 400 agreed to participate. As expected, newborns from SGA group had significantly low birth weight, height and head circumference (P<.001). This group also had the highest percentage of primiparous women in comparison to other groups (P=.005) with exception of CTL. Mothers from SAH group had the highest median age, as well as a higher percentage of cesareans. Additionally, these mothers presented greater gestational weight gain.
Conclusions:
In the present study, we can highlight the main strengths, the planning and structuring of a birth follow-up, considering the scenario of demographic and epidemiological transition in Brazil. Therefore, this follow-up study with its innovative design can bring new insights about causal mechanisms involved in the health and illness in life course.
Citation
