JMIR Publications

ABSTRACT

Background:

Multiple sclerosis (MS) is an inflammatory disease which has wide range of effects of patients. There are controversies regarding the role of vitamin D in clinical and laboratory improvement in MS patients.

Objective:

The aim of this systematic review protocol is to evaluate the efficacy of vitamin D supplements on relapse rate, gadolinium-enhancing lesions of MRI and cytokine profiles.

Methods:

We will search PubMed, Scopus, Web of Science, Ovid, ProQuest, American College of Physicians Journal Club database, Health Technology Assessment Database (The Cochrane Collaboration), and National Health System (NHS), Economic Evaluation Database (The Cochrane Collaboration) and gray literature including reference of included studies, conference abstracts. Clinical trials reporting the effect of any doses of vitamin D on relapse rate, gadolinium-enhancing lesions of MRI and cytokine profiles will be included. Two independent researchers will independently assess the studies, extract data, and assess the quality of primary studies.

Results:

This systematic review was started in September 2017 and the process is continuing. The included articles are evaluated and researchers are going to extract the data.

Conclusions:

This is the first comprehensive systematic review aiming to assess effect of vitamin D supplements on clinical and laboratory findings of MS patients.