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Currently submitted to: JMIR Formative Research

Date Submitted: Sep 27, 2026
Open Peer Review Period: Sep 27, 2026 - Nov 22, 2026
(currently open for review)

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Teaching Critical Appraisal of AI-Generated Output in Medical Education: A Mixed Methods Pilot Study

  • Joseph Cross; 
  • Shinichi Asano; 
  • Caleb Maxson; 
  • Mark Waddell

ABSTRACT

Background:

Medical students need practical opportunities to critically appraise artificial intelligence (AI)-generated clinical output. Comparing model interpretations with an independently formed judgment offers a way to teach this skill within clinical education.

Objective:

To examine learner acceptability, explore changes in confidence and automation-bias-related self-reports, and identify useful features and refinements of an electrocardiogram (ECG)-based AI-appraisal session.

Methods:

This single-center mixed methods pilot involved 13 medical and biomedical sciences students at a US osteopathic medical school. Groups interpreted three ECGs independently, consulted Claude and ChatGPT using a standardized prompt, questioned and compared their outputs, and discussed reference interpretations with faculty. Paired surveys assessed confidence, automation-bias-related responses, learner evaluations, recalled behavior, mental effort, and future intentions. Exact two-sided Wilcoxon signed-rank tests with Holm adjustment across 10 exploratory tests were used for seven confidence and three wording-matched awareness-related items. Two differently worded awareness items and confidence composites were summarized descriptively. Free-text responses underwent AI-assisted descriptive qualitative content analysis and were integrated narratively with survey findings.

Results:

All 13 participants provided complete paired survey data; 11 contributed 40 free-text responses. All participants endorsed curricular inclusion and found the live interactions engaging; 12/13 (92.3%) would recommend the session. The largest mean confidence increase concerned justifying agreement or disagreement with AI, from 4.31 to 6.38 on a 0-10 scale (change 2.08; unadjusted 95% CI 0.77-3.62; Holm-adjusted P=.08). Error-recognition confidence increased from 3.85 to 5.15 (adjusted P=.42). The descriptive AI-appraisal confidence summary increased by 1.69 points, while the ECG-reading summary changed by −0.02 points. No paired test met the multiplicity-adjusted .05 threshold. Six qualitative categories highlighted comparison, questioning and verification, independent reasoning and self-monitoring, preparation, improvements, and collaboration. Six of 11 participants named model comparison as the most useful element, and 11 of 13 endorsed its value for refocusing participants on their own reasoning.

Conclusions:

This pilot identifies a well-received approach to teaching critical appraisal of AI-generated output. Learners valued model comparison and reported opportunities for independent reasoning and reflection, with the largest descriptive confidence changes in AI appraisal. The findings provide a practical instructional sequence and learner-informed refinements for curriculum development and subsequent evaluation of performance and transfer. Clinical Trial: Not applicable.


 Citation

Please cite as:

Cross J, Asano S, Maxson C, Waddell M

Teaching Critical Appraisal of AI-Generated Output in Medical Education: A Mixed Methods Pilot Study

JMIR Preprints. 27/09/2026:112721

DOI: 10.2196/preprints.112721

URL: https://preprints.jmir.org/preprint/112721

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