Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Currently submitted to: Journal of Medical Internet Research

Date Submitted: Sep 22, 2026
Open Peer Review Period: Sep 23, 2026 - Nov 18, 2026
(currently open for review)

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Tailored outreach by predictive modeling: Testing phone call effectiveness between levels of patient risk

  • William Carlton King; 
  • Holly Krelle; 
  • Kyra Rosen; 
  • Simon Jones; 
  • Jay Stadelman; 
  • Blaire Holman; 
  • Mariel Shull; 
  • Leora Horwitz

ABSTRACT

Background:

Telephonic outreach can be an effective but time and resource consuming method to encourage patient outcomes, and often resources are insufficient to reach all patients. Predictive modeling can help determine which patients respond best to outreach, in order to prioritize limited resources to be more effective at achieving patient health outcomes.

Objective:

Test effectiveness of telephonic outreach at different levels of patient likelihood of achieving outcomes, calculated by predictive models based on historical data.

Methods:

Within each of two rapid randomized tests in 2021 and 2022, a predictive model was created using historical data to calculate the likelihood of patients achieving a target health outcome by year end. For Study 1, the outcome was completion of an annual wellness visit. For Study 2, the outcome was reaching 80% percent of days covered (PDC) for a medication prescription. Participants included patients enrolled in a shared savings or risk contract for which the payer made monthly individual-level data available on target measures. Study 1: patients with no active MyChart account due for annual wellness visit between July 1, 2020 and January 31, 2021. Study 2: patients at with at least one unfilled prescription for a cholesterol, diabetes or hypertension medication between July 18 and December 19, 2022. Patients were randomized 1:1 to receive either no outreach (control) or telephonic outreach to encourage patients to complete health outcomes (intervention): Study 1: calls to complete annual wellness visit. Study 2: calls to fill medication prescriptions.

Results:

Study 1: Significantly more patients (n=26,861) completed their annual wellness visit in intervention than control overall (4.5% intervention vs. 0.3% control; RR=13.1; 95% CI: 9.7-17.7) and within each quartile of predicted risk. Study 2: Patient medications (n=6,784) had no significant difference in hitting PDC target between study arms overall (69.8% intervention vs. 68.6% control; RR=1.02, 95% CI: 0.98-1.06), but within the fourth quartile of predicted risk (patients most likely to hit target), intervention subjects were significantly more likely than control to hit their target (81.3% intervention vs. 76.3% control, RR=1.07; 95% CI: 1.01, 1.13).

Conclusions:

Precision medicine can help evaluate the effectiveness of patient outreach for different situations, allowing resources to be targeted to where they have most impact.


 Citation

Please cite as:

King WC, Krelle H, Rosen K, Jones S, Stadelman J, Holman B, Shull M, Horwitz L

Tailored outreach by predictive modeling: Testing phone call effectiveness between levels of patient risk

JMIR Preprints. 22/09/2026:112710

DOI: 10.2196/preprints.112710

URL: https://preprints.jmir.org/preprint/112710

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.