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Currently submitted to: JMIR Formative Research

Date Submitted: Sep 3, 2026

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Theme-Specific Responses to Sustain Talk in AI-Delivered Motivational Interviewing: A Secondary Analysis of Emergency Department Counseling Sessions

  • Carl Preiksaitis; 
  • Denise Walker; 
  • Nikhil Pillai; 
  • Brian Suffoletto

ABSTRACT

Background:

Large language models can generate motivational interviewing-consistent responses, but their responses to client sustain talk require evaluation before clinical use.

Objective:

This formative secondary analysis examined whether sustain-talk themes varied by substance and whether an artificial intelligence counseling agent's response patterns varied by sustain-talk theme.

Methods:

We coded conversational turns from brief counseling sessions with non-treatment-seeking adult emergency department patients focused on alcohol (n=68), cannabis (n=48), or nicotine (n=32). Participant sustain-talk turns were classified into eight themes. Agent responses were coded as discrepancy-only, validation-only, balanced, or neutral-only. Generalized estimating equation models accounted for responses clustered within sessions. Secondary models examined language in the next participant turn.

Results:

Across 477 responses, 50.7% were discrepancy-only, 11.5% validation-only, 8.2% balanced, and 29.6% neutral-only. Relative to therapeutic-coping sustain talk, low-readiness sustain talk was associated with lower odds of discrepancy-only responding (OR, 0.20; 95% CI, 0.08-0.49) and higher odds of validation-only responding (OR, 11.05; 95% CI, 3.87-31.53). In a secondary multinomial model, validation-only responses were associated with a lower relative risk of next-turn sustain talk versus neutral language (RRR, 0.19; 95% CI, 0.09-0.41).

Conclusions:

This formative evaluation identified theme-specific response patterns and potential gaps for prospective testing AI counseling agents. These observational findings support prospective testing of theme-matched response strategies before large-scale deployment. Clinical Trial: NA


 Citation

Please cite as:

Preiksaitis C, Walker D, Pillai N, Suffoletto B

Theme-Specific Responses to Sustain Talk in AI-Delivered Motivational Interviewing: A Secondary Analysis of Emergency Department Counseling Sessions

JMIR Preprints. 03/09/2026:111066

DOI: 10.2196/preprints.111066

URL: https://preprints.jmir.org/preprint/111066

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