Currently accepted at: JMIR Research Protocols
Date Submitted: Jul 6, 2026
Date Accepted: Oct 28, 2026
This paper has been accepted and is currently in production.
It will appear shortly on 10.2196/106341
The final accepted version (not copyedited yet) is in this tab.
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Effectiveness of a digital symptom-matched problem-solving intervention with tailored augmentation for depressive and anxiety symptoms: protocol for a randomized controlled trial
ABSTRACT
Background:
Common mental disorders, including anxiety and depression, require scalable, targeted digital interventions to alleviate symptoms, minimize chronicity and severity, and eventually diminish disease burden.
Objective:
This study aims to examine the efficacy of a symptom-cluster-matched digital problem-solving therapy (PST) intervention for adults experiencing depressive and anxiety symptoms.
Methods:
This study will recruit adults exhibiting symptoms of depression and anxiety from a mental health clinic in Wuhan. Eligible participants will be randomly assigned in a 1:1 ratio to receive either an 8-week symptom-cluster-matched digital PST intervention or psychoeducation. The primary outcomes are depressive and anxiety symptoms. Secondary outcomes encompass functional impairment, sleep disturbance, and quality of life.
Results:
NA
Conclusions:
The findings will yield significant insights into viable techniques for the implementation of personalized and precision psychiatric programs in clinical environments. Clinical Trial: ClinicalTrials.gov (NCT06350201).
Citation
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Copyright
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