Currently submitted to: Journal of Participatory Medicine
Date Submitted: Jun 14, 2026
Open Peer Review Period: Jun 30, 2026 - Aug 25, 2026
(currently open for review)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Endothelium Recovery in Long COVID A Patient-Led Case Study of Endothelial Normalization in a 60-Year-Old Male with 3-Year PASC, Case Report
ABSTRACT
Abstract Background. Long COVID / post-acute sequelae of SARS-CoV-2 infection (PASC) develops in at least 10% of acute SARS-CoV-2 infections and is estimated to affect more than 65 million people worldwide [1]. The condition currently lacks accepted diagnostic biomarkers, effective therapeutic options, and, for many patients, any meaningful clinical support. This paper reports on a patient-led approach to identify the key biochemical processes driving PASC-related symptoms in a single patient, and to successfully treat the patient's most prominent biomarker-confirmed dysfunction: endothelial activation.
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