Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: JMIR Research Protocols

Date Submitted: Jun 17, 2026
Date Accepted: Jul 21, 2026

The final, peer-reviewed published version of this preprint can be found here:

Inspiratory Muscle Training Before Total Joint Arthroplasty to Improve Postoperative Outcomes: Protocol for a Randomized Controlled Trial

Smith BK, Shaner J, Gitlin A, Meier W, Wang S, Ciampitti M, Elijas-Grajeda T, Khan U, Washington J, Freidl M, Braunecker S

Inspiratory Muscle Training Before Total Joint Arthroplasty to Improve Postoperative Outcomes: Protocol for a Randomized Controlled Trial

JMIR Res Protoc 2026;15:e103290

DOI: 10.2196/103290

PMID: 42726784

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Inspiratory Muscle Training to Improve Total Joint Arthroplasty Outcomes: Trial Protocol

  • Barbara K. Smith; 
  • Julie Shaner; 
  • Adam Gitlin; 
  • William Meier; 
  • Sabrina Wang; 
  • Maribel Ciampitti; 
  • Tatiana Elijas-Grajeda; 
  • Ushna Khan; 
  • Johnny Washington; 
  • Michael Freidl; 
  • Stefan Braunecker

ABSTRACT

Total joint arthroplasty (TJA) surgeries are common elective surgeries in the US, and recent care optimization practices have enhanced preoperative readiness. Despite improvements in the efficiency of pre- and post-operative TJA care, even short periods of mechanical ventilation and anesthesia reduce early postoperative lung and respiratory muscle function. In patients undergoing other major surgeries, preoperative inspiratory strength training (IST) reduces the occurrence of post-operative pulmonary complications (PPC’s), but the potential benefits of preoperative IST have not been systematically investigated in shorter surgeries such as TJA with expected brief hospital length of stay. We intend to address this gap in understanding by investigating whether preoperative IST prior to TJA surgery alters respiratory strength, lung function, and functional mobility. The primary study hypothesis is that preoperative IST is feasible and effective to increase inspiratory strength and promote the return of early post-operative respiratory function and functional mobility, in advance of hospital discharge. The study hypothesis will be tested with a randomized, prospective study at a single urban academic health system. Adults scheduled for TJA surgery will be randomized to either undergo daily preoperative IST (dIST), complete an acute IST session in the preoperative area (aIST), or receive clinical standard of care (SOC). Inspiratory muscle strength and pulmonary function will be evaluated upon enrollment at a baseline assessment ~4 weeks in advance of surgery and repeated on the day of surgery. Post-operative changes will be evaluated through the first 24 hours. The study design will establish feasibility and effectiveness of dIST to increase preoperative respiratory strength (Aim 1). We will also compare effects of dIST versus aIST on important post-operative respiratory strength measures and lung function (Aim 2) and 24-hour functional outcomes (Aim 3). This investigation will provide the first controlled study of preoperative IST to optimize respiratory recovery following TJA.


 Citation

Please cite as:

Smith BK, Shaner J, Gitlin A, Meier W, Wang S, Ciampitti M, Elijas-Grajeda T, Khan U, Washington J, Freidl M, Braunecker S

Inspiratory Muscle Training Before Total Joint Arthroplasty to Improve Postoperative Outcomes: Protocol for a Randomized Controlled Trial

JMIR Res Protoc 2026;15:e103290

DOI: 10.2196/103290

PMID: 42726784

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.