JMIR Publications

Background:

Background: The novel coronavirus strain became a pandemic and life-threatening disease worldwide. Despite COVID-19 vaccination in some parts of the world, social distances, lockdowns, and more policies the disease is rising. Early diagnosis is one of the primary keys and main vital steps in disease treatment, especially in life-threatening diseases. Biomarkers are among the primary keys that are taking growing attention. Laboratory parameters are used as biomarkers in disease diagnosis and follow up and COVID-19 is not an exception.

Objective:

Objective: To find the significance of laboratory parameters in the early diagnosis of the disease, expand our knowledge of severe and critically ill patients, and diagnose COVID-19 patients in the early stages, we compared the laboratory values of these patients with the control group.

Methods:

Methods: In this single-center, observational study, we enrolled 143 participants that 103 patients who were severely or critically ill patients with confirmed SARS-CoV-2 pneumonia who were admitted to Imam Khomeini Hospital Complex (Tehran, Iran) and included 40 healthy individuals as the control group. Data were analyzed for demographic data, laboratory values, and clinical outcomes. Data were also compared between survivors and non-survivors.

Results:

Results: Of 143 participants, we enrolled 54 patients in the severe group and 49 patients in the critical group. The average age of the cases was 53.5 years. 52.4% were men, and non-survivors were older than survivors (55 years vs 53.2). Prothrombin time, partial thromboplastin time, the international normalized ratio, D-dimer, WBC, RBC, Hb, HCT, neutrophils, lymphocytes, BUN, Cr, ALT, AST, and ALK were significant in the critical group and the severe group compared to the control group. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were higher in the patient groups compared to the control group. We also carried out a comparison between survivors and non-survivors and revealed that PT, PTT, D-dimer, ESR, FBS, urea, creatinine, LDH, lymphocyte, and neutrophil count were significant.

Conclusions:

Conclusions: Findings showed routine laboratory parameters can give p coagulopathy and organ failure are the main reason for the mortality of patients. Coagulator factors and biochemistry tests screening may help clinicians to monitor Covid patients and predict the prognosis of the disease.

Clinicaltrial: