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Accepted for/Published in: JMIR Medical Education

Date Submitted: Feb 2, 2026
Date Accepted: Aug 11, 2026

The final, peer-reviewed published version of this preprint can be found here:

Effect of Large Language Model–Powered Virtual Standardized Patients on History-Taking Among Undergraduate Medical Students: Propensity-Matched Cohort Study

He Y, Chen C, Yin R, Zhang W, Chang H, Yang W, Li F, Li X, Xia Z, Xie X, Huang J, Zeng Q, Yang G, Chen J, Wu J

Effect of Large Language Model–Powered Virtual Standardized Patients on History-Taking Among Undergraduate Medical Students: Propensity-Matched Cohort Study

JMIR Med Educ 2026;12:e92486

DOI: 10.2196/92486

PMID: 42714021

Effect of Large Language Model–Powered Virtual Standardized Patients on History-Taking Among Undergraduate Medical Students: A Propensity-Matched Cohort Study

  • Yuchen He; 
  • Chen Chen; 
  • Rong Yin; 
  • Wuyang Zhang; 
  • Haoli Chang; 
  • Wei Yang; 
  • Fei Li; 
  • Xinhua Li; 
  • Zhuying Xia; 
  • Xiaoyun Xie; 
  • Jing Huang; 
  • Qiuming Zeng; 
  • Guang Yang; 
  • Junchen Chen; 
  • Jing Wu

ABSTRACT

Background:

Medical history-taking (MHT) is a foundational competency for medical students, yet traditional standardized patient (SP)-based training faces challenges including high costs, management difficulties, and inconsistent standardization. Large language model-powered virtual standardized patients (LLM-VSPs) offer a potential solution by enabling scalable, standardized practice environments.

Objective:

This study aims to explore the effectiveness of using LLM-VSPs in enhancing medical students' MHT skills and the correlation between their practice behaviors and the improvement of MHT skills.

Methods:

A cohort of 168 third-year medical students was allocated to an LLM-VSPs intervention group (Group A, n=120) or a control group (Group B, n=48). Group A completed MHT training using an LLM-VSPs system with real-time feedback, while Group B followed standard curricula. Propensity score matching (PSM) balanced baseline characteristics between groups. Outcomes were assessed through standardized MHT scoring (total score 100: 60 for content, 40 for communication skills). Practice data in Group A were analyzed for correlations with final performance.

Results:

Post-PSM analysis (n=40 per group) demonstrated balanced baselines (standardized mean differences <0.1). Group A achieved significantly higher total MHT scores than Group B (87.7 ± 7.29 vs. 83.7 ± 8.06, p = .023), particularly in terms of the content of MHT (50.2 ± 5.65 vs. 47.4 ± 5.93, p = .031). Within Group A, total practice duration (r = 0.183, p = .046) and average AI-generated assessment score(r = 0.233, p = .010) positively correlated with the final scores, while practice frequency showed no significant association.

Conclusions:

This study demonstrates that LLM-VSPs can enhance MHT skill development more effectively than traditional methods, primarily through enabling deliberate, feedback-driven practice rather than repetitive task accumulation.


 Citation

Please cite as:

He Y, Chen C, Yin R, Zhang W, Chang H, Yang W, Li F, Li X, Xia Z, Xie X, Huang J, Zeng Q, Yang G, Chen J, Wu J

Effect of Large Language Model–Powered Virtual Standardized Patients on History-Taking Among Undergraduate Medical Students: Propensity-Matched Cohort Study

JMIR Med Educ 2026;12:e92486

DOI: 10.2196/92486

PMID: 42714021

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