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Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Oct 26, 2025
Date Accepted: Dec 23, 2025

The final, peer-reviewed published version of this preprint can be found here:

From Agents to Governance: Essential AI Skills for Clinicians in the Large Language Model Era

Cao W, Zhang Q, Liu J, Liu S

From Agents to Governance: Essential AI Skills for Clinicians in the Large Language Model Era

J Med Internet Res 2026;28:e86550

DOI: 10.2196/86550

PMID: 41534067

PMCID: 12853083

From Agents to Governance: Essential AI Skills for Clinicians in the LLM Era

  • Weiping Cao; 
  • Qing Zhang; 
  • Jialin Liu; 
  • Siru Liu

ABSTRACT

Large language models (LLMs) are rapidly transitioning from pilot schemes to routine clinical practice. This creates an urgent need for clinicians to develop the right skills to strike the right balance between seizing opportunities and taking accountability. We propose a three-tier competency framework to support clinicians’ transition from cautious users to responsible stewards of artificial intelligence (AI). Tier 1 (foundational skills) focuses on safe, basic proficiency, encompassing prompt engineering, agentic interaction (supervision, interruption, and manual rollback capability), and core security/privacy awareness. Tier 2 (intermediate skills) emphasizes evaluative expertise, including the critical assessment of bias detection, explainability, trust evaluation, and the effective clinical integration of AI-generated insights. Tier 3 (advanced skills) establishes leadership and governance capabilities, mandating competencies in ethical and regulatory governance, model customization oversight, and advanced model operations, specifically incorporating literacy in predetermined change control plans (PCCP). Integrating this framework into continuing medical education (CME) programmes and job descriptions could enhance clinicians' ability to use AI safely and responsibly. This would help to standardize deployment, improve clinical practice, and ultimately, patient outcomes.


 Citation

Please cite as:

Cao W, Zhang Q, Liu J, Liu S

From Agents to Governance: Essential AI Skills for Clinicians in the Large Language Model Era

J Med Internet Res 2026;28:e86550

DOI: 10.2196/86550

PMID: 41534067

PMCID: 12853083

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