Explore our sister journals here.

Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: Journal of Medical Internet Research

Date Submitted: Aug 21, 2025
Date Accepted: Mar 10, 2026
Date Submitted to PubMed: Mar 11, 2026

The final, peer-reviewed published version of this preprint can be found here:

Efficacy, User Engagement, and Acceptability of Cognitive Behavioral Therapy–Oriented Psychological Chatbots for Adults With Depressive and/or Anxiety Symptoms: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Gong B, Yao N, Xie H, Huang C, Tomoko K, Berenbaum H, Mu W

Efficacy, User Engagement, and Acceptability of Cognitive Behavioral Therapy–Oriented Psychological Chatbots for Adults With Depressive and/or Anxiety Symptoms: Systematic Review and Meta-Analysis of Randomized Controlled Trials

J Med Internet Res 2026;28:e82677

DOI: 10.2196/82677

PMID: 42101333

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Per the author's request this version is not available.