Accepted for/Published in: JMIR Formative Research
Date Submitted: Aug 10, 2025
Date Accepted: Dec 22, 2025
Personalized Informational Support in Hypertension Patients: Feasibility Exploration and Preliminary Changes in Treatment Adherence— A Single-Arm Pre-Post Test Study
ABSTRACT
Background:
Informational support has been demonstrated to enhance patients' treatment adherence. However, which specific mode of informational support is more effective for hypertension patients remains undetermined.
Objective:
The primary objective of this study was to examine the feasibility and effectiveness of an intervention combining in-person follow-ups and telephone counseling among patients with hypertension in a Chinese community setting.
Methods:
A pre-post design was employed to investigate the feasibility of providing informational support intervention to hypertension patients attending a community health facility in Chengdu, China. The intervention combined in-person follow-ups and telephone counseling. Adherence, clinical outcomes (blood pressure, ambulatory blood pressure, and laboratory tests) were measured at baseline and post-intervention. Patients' health behaviors were assessed at baseline and post-intervention using validated structured questionnaires. Descriptive statistics and effect sizes were calculated to determine clinically important changes relative to baseline.
Results:
Significant improvements were observed: medication adherence scores increased by 0.65 points (95% CI: 0.38 to 0.91; P<0.001); Nutrition scores increased by 1.31 points (95% CI: 0.53 to 2.09; P<0.001), interpersonal relations scores increased by 1.17 points (95% CI: 1.03 to 2.02; P=0.007), health responsibility scores increased by 2.42 points (95% CI: 0.33 to 3.80; P=0.001), and the total HPLP-IIR score significantly increased by 6.81 points (95% CI: 3.01 to 10.61; P=0.001) . Night-time systolic blood pressure decreased significantly by 5.07 mmHg (95% CI: -8.12 to -2.01; P=0.001), and night-time diastolic blood pressure decreased significantly by 3.39 mmHg (95% CI: -5.12 to -1.67; P<0.001).
Conclusions:
This study provides preliminary data for a large-scale, adequately powered randomized controlled trial. The findings indicate that providing informational support to community-dwelling patients with hypertension can improve their adherence, enhance health behaviors, and improve blood pressure control. Clinical Trial: This study was registered with the Chinese Clinical Trial Registry under the identifier ChiCTR200003962.
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