Maintenance Notice

Due to necessary scheduled maintenance, the JMIR Publications website will be unavailable from Wednesday, July 01, 2020 at 8:00 PM to 10:00 PM EST. We apologize in advance for any inconvenience this may cause you.

Who will be affected?

Accepted for/Published in: JMIR Serious Games

Date Submitted: Jun 24, 2025
Open Peer Review Period: Jun 24, 2025 - Aug 19, 2025
Date Accepted: Dec 29, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Feasibility and User Experience of Immersive Virtual Reality–Based Rehabilitation in Patients With Stroke: Single-Arm Pretest-Posttest Pilot Study

Arlati S, Mondellini M, Martinelli I, Guanziroli E, Rossini M, Sacco M, Molteni F

Feasibility and User Experience of Immersive Virtual Reality–Based Rehabilitation in Patients With Stroke: Single-Arm Pretest-Posttest Pilot Study

JMIR Serious Games 2026;14:e79584

DOI: 10.2196/79584

PMID: 41812077

Feasibility and User Experience during Immersive Virtual Reality-based Rehabilitation in Patients with Stroke: Single-Arm Pretest-Posttest Pilot Study

  • Sara Arlati; 
  • Marta Mondellini; 
  • Isabella Martinelli; 
  • Eleonora Guanziroli; 
  • Mauro Rossini; 
  • Marco Sacco; 
  • Franco Molteni

ABSTRACT

Background:

Immersive Virtual Reality (VR) is promising in stroke rehabilitation; however, existing work often lacks a structured assessment of user experience over a long period.

Objective:

To assess user experience in patients with stroke before and after a training period of 4 weeks, in which they used a VR application to train upper limb and cognitive functions

Methods:

Thirty-two chronic or post-acute patients with stroke were enrolled. They all performed 4 weeks of training, performing exercises in the Virtual Supermarket for Stroke (VSS). The VSS had a series of features allowing for the customization of the level of difficulty to make the task more and more challenging throughout the trial. We assessed subjective outcomes after the first and the last session. Clinical scales were also administered at the baseline and at the end of the treatment.

Results:

Flow (4.56, iqr: 0.68 up to 5), sense of presence, and affective state-related variables were satisfactory after the first session. No severe symptoms of cybersickness occurred (SSQ-TS: 11.22, iqr: 20.57). At the end of the intervention program, we did not record any significant differences in any subjective variable. Regarding clinical outcomes, we recorded a significant improvement in balance (Berg Balance Scale PRE: 30, iqr: 31.8; POST: 33.5, iqr: 30), upper limb motor functions (Motricity Index PRE: 45, iqr: 53.75; POST: 46.0, iqr: 45; Box and Block PRE: 0, iqr: 11.5, POST: 0, iqr: 28), and functional mobility (Time Up and Go PRE: 18, iqr: 21.25; POST: 14, iqr: 17).

Conclusions:

The positive experience, possibly mediated by the ease of use and the customized level of challenge, was preserved through the 4 weeks of training. Clinical scales suggested that the VSS also allowed the training of executive functions and promoted neuroplasticity, even in chronic patients. Further studies with larger samples are needed to confirm these results. Clinical Trial: not applicable


 Citation

Please cite as:

Arlati S, Mondellini M, Martinelli I, Guanziroli E, Rossini M, Sacco M, Molteni F

Feasibility and User Experience of Immersive Virtual Reality–Based Rehabilitation in Patients With Stroke: Single-Arm Pretest-Posttest Pilot Study

JMIR Serious Games 2026;14:e79584

DOI: 10.2196/79584

PMID: 41812077

Download PDF


Request queued. Please wait while the file is being generated. It may take some time.

© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.