JMIR Publications

ABSTRACT

Dermal fillers have gained popularity in recent years for their ability to restore volume, smooth wrinkles, and enhance facial contours. The use of fillers in cancer patients undergoing active antineoplastic therapy presents specific challenges, as these treatments may impact both the safety and efficacy of filler applications. These therapies may interfere with the typical healing process and immunological responses, which necessitates a more cautious approach to the use of dermal fillers in patients receiving antineoplastic treatment. Dermal fillers can cause complications such as cellulitis, Autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA), and can predispose patients to additional malignancies. Adverse effects of filler include localized inflammatory, systemic hypersensitivity, and delayed granulomatous formation. Overall, there has been minimal research conducted on the topic of dermal filler and antineoplastic/radiation treatment, however there are three published case studies describing reactions in patients receiving antineoplastic therapy that are highly variable. Chemotherapy is often paired with adjuvant radiation therapy in cancer treatment, making it important to note the potential changes radiation can also have on the skin. More research is needed to examine the direct interactions of chemotherapy and radiation on various filler materials injected within the skin, and how these interactions can alter the risk of specific complications or adverse effects. The lack of research on this topic further emphasizes that clinicians should thoroughly educate patients receiving chemotherapy and adjuvant radiation treatment about the heightened potential risks associated with dermal filler injections.