Accepted for/Published in: Interactive Journal of Medical Research
Date Submitted: Apr 1, 2025
Open Peer Review Period: Apr 2, 2025 - May 28, 2025
Date Accepted: Jun 5, 2025
(closed for review but you can still tweet)
Safety and efficacy of aspirin and indobufen in the treatment of atherosclerotic diseases: a systematic review and meta-analysis
ABSTRACT
Background:
The pathogenesis of atherosclerotic thrombosis primarily involves platelet activation and aggregation, making antiplatelet therapy the cornerstone of treatment for such diseases.
Objective:
This meta-analysis aimed to compare the safety and efficacy of aspirin and indobufen in antiplatelet therapy for patients with arteriosclerotic cardiovascular disease.
Methods:
We searched the Cochrane Library, PubMed, EMBASE, Web of Science, and the Chinese Wanfang databases. The literature was screened according to predefined inclusion and exclusion criteria. Relative risk (RR) was used to assess the magnitude of risk associated with exposure.
Results:
Eighteen clinical trials with a total of 12981 patients were included in this study. Compared with aspirin, indobufen reduced the risk of (1) bleeding events (RR 0.54; 95% CI: 0.41–0.71; P < 0.0001), (2) BARC 2/3/5 bleeding (RR 0.50; 95% CI: 0.26–0.94; P = 0.03), (3) adverse cardiovascular events (RR 0.43; 95% CI: 0.30–0.61; P < 0.00001), and (4) myocardial infarction (RR 0.60; 95% CI: 0.41–0.89; P = 0.01). However, there were no significant differences between the two groups in terms of MACCEs, stroke, or cardiovascular mortality.
Conclusions:
Compared to aspirin, indobufen demonstrated better safety and was not inferior to aspirin in terms of efficacy, with superior results in some aspects. Further studies with larger sample sizes or longer follow-up periods may provide additional evidence. Clinical Trial: This study is registered with PROSPERO (CRD42024588250) and was conducted in accordance with the 2020 version of the PRISMA statement
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