Accepted for/Published in: JMIR Research Protocols
Date Submitted: Mar 26, 2025
Date Accepted: Jun 16, 2025
Epidemiology and impact of a staff training in controlling complications related to central venous catheter in 4 intensive care units in a French University Hospital: Protocol of a Prospective Quasi-Experimental before-after Study
ABSTRACT
Background:
Central venous catheters (CVCs) are essential tools in intensive care units (ICUs) but are associated with infectious, mechanical and thrombotic complications. Despite established clinical guidelines, variability in adherence persists, contributing to preventable morbidity and mortality. In 2022, an audit at Edouard Herriot Hospital (Hospices Civils de Lyon (HCL), Lyon, France) revealed a degree of variation in adherence to current protocols. Speficifically, certain practices were not in accordance with evidence-based recommendations, particularly hand hygiene, flushing procedures, asepsis, among others.
Objective:
This study aims to evaluate the impact of an educational program on adherence to national guidelines for CVC management, assess its effect on clinical outcomes, and identify factors associated with CVC-related complications.
Methods:
A prospective quasi-experimental cross-over study is ongoing in four ICUs at a French university hospital. The design includes audits, educational sessions based on the recommendations of the French Society of Hospital Hygiene, and clinical data on patients with CVC.
Results:
Compliance and complication rates will be assessed before and after the intervention. The primary outcome is the rate of CVC-related complications per catheter-days. Secondary outcomes include rehospitalizations, mortality, and adherence improvement.
Conclusions:
This study will evaluate the efficacy of an educational program in enhancing adherence to national guidelines and improving clinical outcomes. Ultimately, this initiative will offer a reproducible model for other institutions seeking to enhance care quality and mitigate patient risks.
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