Accepted for/Published in: JMIR Public Health and Surveillance
Date Submitted: Mar 11, 2025
Date Accepted: Apr 20, 2026
Triglyceride-glucose Index and Risk of End-stage Kidney Disease in Young Adults: A National Population-based Cohort Study
ABSTRACT
Background:
The triglyceride-glucose (TyG) index, a simple marker of insulin resistance, is associated with chronic kidney disease (CKD) and end-stage kidney disease (ESKD). However, its association with ESKD in young adults remains unexplored.
Objective:
This study aimed to investigate whether the TyG index increases the risk of ESKD in young adult population.
Methods:
This nationwide retrospective, population-based cohort study analyzed data from 6,555,863 individuals aged 20–39 years between January 2009 and December 2012 using the Korean National Health Insurance Database. Participants were categorized into quartiles and deciles based on the TyG index. The cumulative incidence and adjusted hazard ratios (aHRs) for ESKD were assessed.
Results:
Over a median follow-up period of 10.61 years, 4,910 (0.75%) participants developed ESKD. The incidence of ESKD increased with a higher TyG index in quartiles and deciles. The aHR for ESKD in the highest quartile was 3.469 (95% confidence interval [CI]: 3.122–3.854) compared to the lowest quartile, and that in the highest decile was 5.951 (95% CI: 5.026–7.046) compared to the lowest decile. These associations remained consistent across subgroup analyses by to age, sex, obesity, dyslipidemia, and CKD.
Conclusions:
The TyG index is a strong and independent predictor of ESKD risk in young adults.
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.