JMIR Publications

ABSTRACT

Background:

Physical activity (PA) and sleep during pregnancy may mitigate the increased risk for adverse pregnancy outcomes posed by gestational diabetes and high gestational weight gain in pregnant individuals with pre-pregnancy overweight and obesity. Recent studies have conceptualized PA, sedentary behavior, and sleep as part of a 24-hour movement framework; however, there is a gap in knowledge about the relationship between 24-hour movement and pregnancy outcomes.

Objective:

This paper describes the study protocol for the 24MOVE study, a prospective cohort study that examines associations between 24-hour movement profiles across pregnancy and maternal glucose tolerance, gestational weight gain, and infant birthweight.

Methods:

Participants (n=306) were recruited from a large, integrated health care delivery system at 10 weeks gestation. In early (10-12 weeks), mid (20-22 weeks), and late (33-35 weeks) pregnancy, all eligible individuals with a pre-pregnancy BMI of ≥25 kg/m2 completed online surveys collecting information on sociodemographic characteristics and pregnancy symptoms and behaviors, including sleep quality. Participants concurrently wore a research-grade accelerometer for 24 hours per day for 7 consecutive days to capture movement, sedentary behavior, and sleep data. Data from accelerometry will be processed to create 24-hour movement profiles. Pregnancy outcomes will be ascertained from the electronic health record. We will use compositional data analysis methods, modeling associations of reallocations of time from one component behavior to another at various timepoints with outcomes.

Results:

Over an 18-month recruitment period, 2,035 individuals were invited to participate and of those, 306 eligible participants enrolled in this study. The enrolled cohort had a median age of 33 years and BMI of 28.8 kg/m². Most participants had private insurance (87%) and were multiparous (76%). Follow-up data collection is ongoing.

Conclusions:

The 24MOVE Study is designed to address gaps in our knowledge of the impact of 24-hour movement during pregnancy on maternal glucose metabolism, gestational weight gain, and other risk factors for childhood obesity, such as high birthweight. Data from this study will also serve as a rich resource for future investigations of 24-hour movement profiles and behavior substitutions and other perinatal mental and physical health outcomes.