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Accepted for/Published in: JMIR Medical Informatics

Date Submitted: Feb 12, 2025
Date Accepted: Jun 24, 2025

The final, peer-reviewed published version of this preprint can be found here:

Deep Learning–Based Early Warning Systems in Hospitalized Patients at Risk of Code Blue Events and Length of Stay: Retrospective Real-World Implementation Study

Sim T, Kim Jh, Cho EY, Choi Y, Lee Kb, Kim KJ, Won JY, Kim HG, Cheon SH, Kim YA

Deep Learning–Based Early Warning Systems in Hospitalized Patients at Risk of Code Blue Events and Length of Stay: Retrospective Real-World Implementation Study

JMIR Med Inform 2025;13:e72232

DOI: 10.2196/72232

PMID: 40845828

PMCID: 12373407

Deep Learning–Based Early Warning Systems in Hospitalized Patients at Risk of Code Blue Events and Length of Stay: Retrospective Real-world Implementation Study

  • Taeyong Sim; 
  • Ji-hyun Kim; 
  • Eun Young Cho; 
  • Yuhyun Choi; 
  • Ki-byung Lee; 
  • Kwang Joon Kim; 
  • Joo-Yun Won; 
  • Ho Gwan Kim; 
  • Se Hee Cheon; 
  • Young Ae Kim

ABSTRACT

Background:

In-hospital Code Blue is an emergency that refers to a patient requiring immediate resuscitation. Over 85% of cardiopulmonary arrest patients exhibit abnormal vital sign trends prior to the event. Continuous monitoring and accurate interpretation of clinical data through artificial intelligence (AI) models can contribute to preventing critical events.

Objective:

To evaluate changes in clinical outcomes following the use of VitalCare (VC) (Major Adverse Event Score (MAES) and Mortality Score (MORS)), which is an AI-based early warning system, and to validate the performance of the algorithm.

Methods:

A retrospective analysis was conducted by extracting electronic health record data, utilizing a total of 30,785 inpatient cases from general wards and intensive care units. A comparative analysis was performed by setting a three-month period before and after the system implementation. For clinical evaluation, we measured the incidence rates of Code Blue and adverse events, proportion of prolonged hospitalization, and frequency of early interventions. The area under the receiver operating characteristic curve (AUROC) was calculated to assess the performance of the algorithm.

Results:

This study demonstrated that, following the implementation of VC, there was a reduction in major events such as Code Blue and the proportion of prolonged hospitalization in general wards, along with a significant increase in the rate of early interventions. The model performance exhibited superior outcomes compared with traditional scoring systems, with an MAES AUROC of 0.866 and MORS AUROC of 0.938.

Conclusions:

A well-developed AI-based model that provides high predictive power can contribute to the prevention of major in-hospital events by providing early predictive information to clinicians. In addition, it plays a crucial role in effectively addressing unmet needs and challenges in terms of human resources and practical procedures.


 Citation

Please cite as:

Sim T, Kim Jh, Cho EY, Choi Y, Lee Kb, Kim KJ, Won JY, Kim HG, Cheon SH, Kim YA

Deep Learning–Based Early Warning Systems in Hospitalized Patients at Risk of Code Blue Events and Length of Stay: Retrospective Real-World Implementation Study

JMIR Med Inform 2025;13:e72232

DOI: 10.2196/72232

PMID: 40845828

PMCID: 12373407

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