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Accepted for/Published in: JMIR Mental Health

Date Submitted: Nov 7, 2024
Open Peer Review Period: Oct 31, 2024 - Dec 26, 2024
Date Accepted: Jan 28, 2025
(closed for review but you can still tweet)

The final, peer-reviewed published version of this preprint can be found here:

Telehealth-Based vs In-Person Aerobic Exercise in Individuals With Schizophrenia: Comparative Analysis of Feasibility, Safety, and Efficacy

Kimhy D, Ospina LH, Wall M, Alschuler DM, Jarskog LF, Ballon JS, McEvoy J, Bartels MN, Buchsba Ru, Goodman M, Miller SA, Stroup TS

Telehealth-Based vs In-Person Aerobic Exercise in Individuals With Schizophrenia: Comparative Analysis of Feasibility, Safety, and Efficacy

JMIR Ment Health 2025;12:e68251

DOI: 10.2196/68251

PMID: 39951622

PMCID: 11844875

Comparison of Feasibility, Safety, and Efficacy of Telehealth-Based vs. In-Person Aerobic Exercise in Individuals with Schizophrenia

  • David Kimhy; 
  • Luz H. Ospina; 
  • Melanie Wall; 
  • Daniel M. Alschuler; 
  • Lars F. Jarskog; 
  • Jacob S. Ballon; 
  • Joseph McEvoy; 
  • Matthew N. Bartels; 
  • Richard um Buchsba; 
  • Marianne Goodman; 
  • Sloane A. Miller; 
  • T. Scott Stroup

ABSTRACT

Background:

Aerobic exercise (AE) training has been shown to enhance aerobic fitness in people with schizophrenia. Traditionally, such training has been administered in-person. However, following the advent of the COVID-19 pandemic, many clinics transitioned their services to telehealth-based delivery. Yet, at present there is scarce information about the feasibility, safety, and efficacy of telehealth-based AE in this population.

Objective:

Examine the feasibility, safety, and efficacy of telehealth-based AE in individuals with schizophrenia.

Methods:

We analyzed data from the AE arm of a single-blind, randomized clinical trial examining the impact of a 12-week AE intervention in people with schizophrenia. Following the onset of the COVID-19 pandemic, the AE trial intervention transitioned from in-person to telehealth-based delivery of AE, with the training frequency and duration remaining identical. We compared the feasibility, safety, and efficacy of AE training among participants in the in-person (pre-COVID-19) vs. the telehealth AE (post-COVID-19).

Results:

The telehealth-based AE was associated with significantly lower drop-out rate. There were no significant group differences in total time spent exercising, however the telehealth group had significantly lower proportion of session-time exercising at or above target intensity. There were no AE-related serious adverse events associated with either format. There were no significant differences in the proportion of patients with any AE-related minor/moderate adverse events (e.g. muscle soreness, joint pain, blisters, dyspnea). There were no significant differences between the in-person vs. telehealth groups regarding changes in aerobic fitness indexed by VO2max.

Conclusions:

Our findings provide preliminary support for the deployment of telehealth-based AE for individuals with schizophrenia. We discuss the findings’ clinical implications, along with potential implementation challenges. Clinical Trial: ClinicalTrials.gov Identifier NCT03270098


 Citation

Please cite as:

Kimhy D, Ospina LH, Wall M, Alschuler DM, Jarskog LF, Ballon JS, McEvoy J, Bartels MN, Buchsba Ru, Goodman M, Miller SA, Stroup TS

Telehealth-Based vs In-Person Aerobic Exercise in Individuals With Schizophrenia: Comparative Analysis of Feasibility, Safety, and Efficacy

JMIR Ment Health 2025;12:e68251

DOI: 10.2196/68251

PMID: 39951622

PMCID: 11844875

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