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Accepted for/Published in: JMIR Research Protocols

Date Submitted: Sep 27, 2024
Date Accepted: Feb 14, 2025

The final, peer-reviewed published version of this preprint can be found here:

Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomized Controlled Trial

Wright K, Richards Adams IK, Helsabeck NP, Rose KM, Moss KO, Nemati, D, Palmer N, Kim B, Pokhrel Bhattarai S, Nguyen C, Addison D, Klatt MD

Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomized Controlled Trial

JMIR Res Protoc 2025;14:e66975

DOI: 10.2196/66975

PMID: 40146982

PMCID: 11986388

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

Stress and hypertension among African American women family caregivers of persons living with Alzheimer's disease and related dementias: Randomized controlled pilot study protocol

  • Kathy Wright; 
  • Ingrid K. Richards Adams; 
  • Nathan P Helsabeck; 
  • Karen M. Rose; 
  • Karen O. Moss; 
  • Donya Nemati,; 
  • Navia Palmer; 
  • Bohyun Kim; 
  • Sunita Pokhrel Bhattarai; 
  • Christopher Nguyen; 
  • Daniel Addison; 
  • Maryanna D. Klatt

ABSTRACT

Background:

Caregivers of persons living with Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) tend to neglect their health, including by ignoring their stress levels. African American women are particularly vulnerable to this, and they are also particularly susceptible to hypertension. Addressing stress reactivity/stress resilience is vital in lessening their stress related to caregiving, enhancing their quality of life, and fostering healthy blood pressure self-care behaviors

Objective:

This pilot study aims to investigate the feasibility and acceptability of implementing the Mindfulness in Motion (MIM) plus the Dietary Approaches to Stop Hypertension intervention (MIM DASH) in this population and to evaluate its effect on AD/ADRD caregivers’ stress and quality of life. Additionally, the study explores the mediating role of stress reactivity/stress resilience between interventions and self-care behaviors.

Methods:

A small RCT pilot study will recruit 28 African American/Black female caregivers aged 40 years or older living with hypertension. Participants will be randomly assigned to either the MIM DASH intervention or the Alzheimer’s Association Caregiver Training group (attention control). Both interventions will be delivered over eight weeks through one-hour group telehealth sessions, accessible via video or telephone. After completing the health intervention, both groups will receive coaching calls over nine months, beginning with eight weekly calls followed by four monthly calls to encourage participants to utilize the educational materials.

Results:

This study is an ongoing project. Recruitment, intervention delivery, and fidelity monitoring have been completed. Final data collection and analysis will occur by December 2024.

Conclusions:

Our research will be pioneering in elucidating the mechanisms underlying stress reactivity/stress resilience, exploring African American female caregivers' psychological and physiological responses to stress, and investigating their self-care behaviors. These insights will pave the way for a larger randomized controlled trial to evaluate the effects of MIM DASH among African American female caregivers of persons living with dementia. Clinical Trial: NCT05721482


 Citation

Please cite as:

Wright K, Richards Adams IK, Helsabeck NP, Rose KM, Moss KO, Nemati, D, Palmer N, Kim B, Pokhrel Bhattarai S, Nguyen C, Addison D, Klatt MD

Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomized Controlled Trial

JMIR Res Protoc 2025;14:e66975

DOI: 10.2196/66975

PMID: 40146982

PMCID: 11986388

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