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Accepted for/Published in: JMIR Nursing

Date Submitted: Dec 29, 2024
Date Accepted: Sep 26, 2025

The final, peer-reviewed published version of this preprint can be found here:

An Expert Knowledge Algorithm and Model Predicting Wound Healing Trends for a Decision Support System for Pressure Injury Management in Home Care Nursing: Development and Validation Study

Kitamura A, Ando A, Nakagami G, Sanada H

An Expert Knowledge Algorithm and Model Predicting Wound Healing Trends for a Decision Support System for Pressure Injury Management in Home Care Nursing: Development and Validation Study

JMIR Nursing 2025;8:e65716

DOI: 10.2196/65716

PMID: 41364745

PMCID: 12688022

An expert knowledge algorithm and model predicting wound healing trends for a decision support system for pressure injury management in home care nursing: Development and validation study

  • Aya Kitamura; 
  • Aruto Ando; 
  • Gojiro Nakagami; 
  • Hiromi Sanada

ABSTRACT

Background:

Home-visiting nurses have difficulty selecting appropriate pressure injury (PI) management despite using clinical practice guidelines in various home-visiting settings. Clinical decision support systems (CDSS) can help home-visiting nurses’ decision-making.

Objective:

This study aimed to develop a care algorithm reflecting the expertise of a wound expert nurse and a predictive model for the change of PI severity to inform home-visiting nurses to receive actual consultation.

Methods:

First, an existing algorithm was modified by semi-structured interviews with a certified wound expert nurse. Case information was input into both base and high-expertise algorithms, which provided care recommendations across nine fields: 1) pressure relief, 2) nutritional management, 3) shear relief, 4) moisture management, 5) wound dressing use, 6) care for physical factors including bone prominence, obesity, joint contractures, and periwound edema, 7) care for systemic disorder, 8) selection of wound dressings, ointments, and negative pressure wound therapy, and 9) wound cleansing. An expert interviewee assessed the high-expertise algorithm’s recommendations on a five-point scale, comparing them to the base algorithm and their own clinical judgment. To measure the algorithm’s applicability, agreement proportions were calculated as the number of vignettes where the care recommendation was considered appropriate/total number of vignettes. To measure the algorithm’s alignment, improvement proportions were calculated as the number of vignettes where the care recommendation improved/total number of vignettes excluding vignettes when the existing and high-expertise algorithm both showed an appropriate recommendation. Expected healing levels were evaluated by a 4-point scale where four indicates the high-expertise algorithm can “much improve” the case. Second, predictive distributions of changes of DESIGN-R®2020 score, PI severity score, were estimated with a hierarchical Bayesian model. The best model determined using training data (n=42) calculated coverage probabilities of 90% prediction interval in test data (n=34). The coverage probability of 90% prediction interval was defined as follows: the number of times when actual scores were within the 90% prediction interval/the number of assessments when the prediction was conducted.

Results:

The agreement proportions were 0.92, 0.75, and 0.89, respectively. The improvement proportions were 0.73, 0.25, and 0.76, respectively. The expected healing level was 2.67, 3.00, and 3.25, respectively. Coverage probabilities of 90% prediction interval in the test data were 0.67, 0.83, 0.86, and 0.80, respectively.

Conclusions:

This study developed an algorithm reflecting the expertise and a model to estimate predictive distributions of changes of DESIGN-R®2020 score for developing clinically applicable CDSS for home-visiting nurses providing appropriate PI management. Clinical Trial: Not applicable.


 Citation

Please cite as:

Kitamura A, Ando A, Nakagami G, Sanada H

An Expert Knowledge Algorithm and Model Predicting Wound Healing Trends for a Decision Support System for Pressure Injury Management in Home Care Nursing: Development and Validation Study

JMIR Nursing 2025;8:e65716

DOI: 10.2196/65716

PMID: 41364745

PMCID: 12688022

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