Accepted for/Published in: JMIR Research Protocols
Date Submitted: Aug 6, 2024
Date Accepted: Dec 26, 2024
Role of Injectable Platelet-rich Fibrin in the Management of Soft and Hard Tissue Periodontal Regeneration in Dentistry: Protocol for a Systematic Review
ABSTRACT
Background:
The capacity of injectable platelet-rich fibrin to release greater amounts of several growth factors, as well as to stimulate increased fibroblast migration and collagen, TGF-β, and PDGF expression, was revealed. Consequently, i-PRF can be used as a bioactive agent to promote tissue regeneration.
Objective:
To compare and evaluate the effectiveness of Injectable platelet-rich fibrin in soft and hard tissue regeneration in dentistry
Methods:
We will conduct an electronic search in the following databases: PubMed, Cochrane Library, Google Scholar, Semantic Scholar, Scopus, and Web of Science, with restrictions on the use of the English language, for randomised controlled trials comparing PRF or any other biomaterial with the I-PRF in soft and hard tissue regeneration during dental treatment. The included articles in this review and the reference lists of pertinent reviews will be manually searched. The selection of studies, data extraction, and assessment will be carried out separately by two reviewers utilising the Risk of Bias 2 (RoB 2) method for included research.
Results:
The success of I-PRF will be evaluated by comparing the mean difference regeneration of soft and hard tissues in terms of gingival recession, probing pocket depth, clinical attachment level, and gingival width. Together with the associated 95% confidence intervals, the combined effect size measurements will be estimated using a fixed effect model.
Conclusions:
Injectable platelet-rich fibrin is efficacious in soft and hard tissue regeneration in dentistry. Clinical Trial: This trial is registered under PROSPERO with registration number: CRD42023464250. https://www.crd.york.ac.uk/prospero/#recordDetails
Citation
Request queued. Please wait while the file is being generated. It may take some time.
Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.