Accepted for/Published in: JMIR Research Protocols
Date Submitted: Jul 5, 2024
Date Accepted: Apr 15, 2025
Single stage versus two stage facial reanimation with a free functional muscle flap: A Systematic Review Protocol
ABSTRACT
Background:
Facial paralysis is a condition that arises from several aetiologies that is associated with significant physical and psychosocial complications. Classically, two stage facial reanimation was used to treat patients with unilateral facial paralysis however single stage facial reanimation has seen an increase in usage. Studies comparing both techniques are limited and to the best of our knowledge there are no systematic reviews that compare these techniques.
Objective:
To perform a systematic review that explores how the outcomes of single stage facial reanimation with a free functional muscle flap(s) compare against two stage facial reanimation.
Methods:
This systematic review protocol was written according to PRISMA-P and NICE guidelines. The search strategy will be conducted in three stages: electronic databases (MEDLINE, EMBASE, Web of Science Core Collection), trial registers (Clinicaltrials.org), and snowballing. Studies published from 1995 to 2024 will be screened using an inclusion and exclusion criteria. Data will be extracted into a standardised spreadsheet and the risk of bias and quality of evidence will be assessed. Two reviewers will screen, extract, and assess included studies. Discrepancies will be discussed and rectified with a third reviewer if needed. A narrative synthesis of findings will be performed and presented with descriptive and statistical analysis, where possible, using the GraphPad Prism software.
Results:
The review will formally begin in July 2024 and will be performed and reported according to this protocol and the PRISMA guidelines. A PRISMA flowchart will be used to summarise the search and study selection. A narrative synthesis and tables will be used to summarise the results of the included studies. Where possible, statistical analyses also be presented using graphs and figures.
Conclusions:
This systematic review will aim to summarise outcomes of single and two stage facial reanimation and explore differences between these surgical techniques, if any. The results will provide updated information for patients and clinicians. Moreover, the review may help identify potential areas for further research and policy development. Clinical Trial: PROSPERO 2024 CRD42024556255
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Copyright
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