Accepted for/Published in: JMIR Formative Research
Date Submitted: May 20, 2024
Open Peer Review Period: May 20, 2024 - Jul 15, 2024
Date Accepted: Oct 19, 2024
(closed for review but you can still tweet)
Minimal Clinically Important Difference With App-Based Japanese Allergic Conjunctival Diseases Quality of Life Questionnaire Outcomes: A Cross-Sectional, Observational Study
ABSTRACT
Background:
A minimal clinically important difference (MCID) that can be applied to assess Domain II of the Japanese Allergic Conjunctival Disease Quality of Life Questionnaire (JACQLQ) in a smartphone application (app) setting has yet to be determined.
Objective:
The aim of this cross-sectional, observational study was to determine MCIDs for the app-based JACQLQ in assessing hay fever-related allergic conjunctivitis.
Methods:
The face scale of the JACQLQ Domain III and stress level scale for hay fever were used as anchors to estimate the MCID; ranges were derived from these MCID estimates.
Results:
A total of 7,590 participants with hay fever were included in the study. MCID ranges calculated using the anchor-based method were 1.0–6.9, 1.2–5.6, and 2.1–12.6 for daily activity, psychological well-being, and total JACQLQ Domain II scores, respectively. The distribution-based method resulted in two MCIDs based on half the standard deviation and standard error of measurement for daily activity (4.8 and 4.2), psychological well-being (3.4 and 3.1), and total JACQLQ Domain II (7.8 and 6.4) scores. Suggested MCID ranges for daily activity, psychological well-being, and total JACQLQ Domain II scores were 4.2–6.0, 3.1–4.7, and 6.4–10.5, respectively.
Conclusions:
MCID ranges for the JACQLQ estimation could help to standardize app-based quality of life assessment for patients with hay fever-related allergic conjunctivitis. Clinical Trial: Not applicable.
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