Accepted for/Published in: JMIR Research Protocols
Date Submitted: May 9, 2024
Open Peer Review Period: May 14, 2024 - Jul 5, 2024
Date Accepted: Jul 23, 2024
(closed for review but you can still tweet)
Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Intervention Development for Project TEACH (Tailored Education for Aging and Cognitive Health) for Dementia Prevention in Midlife Adults: Design and Protocol for Pilot Randomized Controlled Trial
ABSTRACT
Background:
Twelve modifiable risk factors account for 40% of dementia cases globally, yet population adherence to health behaviors associated with these factors is low. Midlife is a critical window for dementia prevention, as brain pathology often begins to accumulate years or decades before the onset of symptoms. Although multidomain behavioral interventions have been efficacious for reducing risk of cognitive decline, adherence is low. Intrapersonal factors, such as health beliefs, are known mediators of the relationship between knowledge and health behavior. Method/Design: In keeping with Stage I of the NIH Stage Model for Behavioral Intervention Development, this study will use mixed methods to 1) develop an enhanced health education intervention, including an explanatory method for communicating information about dementia risk and personal health beliefs; and 2) conduct a pilot randomized controlled trial (N=20 per intervention arm) over 8 weeks to assess feasibility of delivering the enhanced intervention versus basic health education alone. Proximal outcomes (measured at baseline, 4 weeks, and 8 weeks) include perceived threat of Alzheimer’s disease, dementia awareness, and self-efficacy. Conclusion: Study findings will reveal the feasibility of delivering an 8-week multi-domain health education intervention for primary prevention of dementia in midlife and will provide preliminary evidence of mechanisms of change.
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