A Longitudinal Analysis of Public Interest in Acetyl Hexapeptide-8
ABSTRACT
Background:
Acetyl hexapeptide-8, also known as Argireline, is a topical, short-acting, synthetic peptide which has recently gained popularity for its anti-wrinkle effects. This agent has emerged as a more accessible alternative to Botulinum neurotoxin (BoNT).
Objective:
This study evaluates public interest of acetyl hexapeptide-8 in the United States from 2013 to 2023, as described by search volume on Google, the most-used search engine.
Methods:
Longitudinal relative monthly search volume from January 1, 2013, to January 1, 2023, was analyzed for acetyl hexapeptide-related terms. Internet search trends for “Botox” during this period were compared to “Argireline.”
Results:
Terms “Argireline” and “Botox in a bottle” both had substantial increases in search volume in 2022. Although its search volume is drastically increasing, “Argireline” was less searched than “Botox,” which had a stable, up-trending search volume over the past decade.
Conclusions:
The increasing interest in acetyl hexapeptide-8 may be due to its cost efficacy and use as a BoNT alternative. Affordability, over-the-counter availability, and ease of self-application of the agent suggest its potential to enhance accessibility to cosmetic dermatologic care.
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