Accepted for/Published in: JMIR Research Protocols
Date Submitted: Oct 29, 2023
Open Peer Review Period: Oct 29, 2023 - Dec 24, 2023
Date Accepted: Mar 15, 2024
(closed for review but you can still tweet)
Multivisceral oncological resections involving the pancreas - a protocol for a Systematic Review and Meta-Analysis
ABSTRACT
Background:
With the continuous advancement of cancer treatments, a comprehensive analysis of the impact of multivisceral oncological pancreatic resections on morbidity, mortality, and long-term survival is currently lacking.
Objective:
This manuscript presents the protocol for a systematic review and meta-analysis designed to summarize the existing evidence concerning the outcomes of multivisceral oncological pancreatic resections across diverse tumor entities.
Methods:
We will conduct a systematic search of the PubMed/MEDLINE, Embase, Cochrane Library, CINAHL, and ClinicalTrials.gov databases in strict accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The predefined outcomes encompass postoperative mortality, postoperative morbidity, overall and disease-free survival (1- to 5-year survival rates), the proportion of macroscopically complete (R0) resections (according to the Royal College of Pathologists definition), duration of hospital stay (in days), reoperation rate (%), postoperative complications (covering all complications according to the Clavien-Dindo classification) as well as pancreatic fistula, post-pancreatectomy hemorrhage and delayed gastric emptying (all according to the definitions of the International Study Group of Pancreas Surgery).
Results:
Systematic database searches will begin in October 2023. The completion of the meta-analysis is anticipated by December 2024.
Conclusions:
The forthcoming findings will provide an up-to-date overview of the feasibility, safety, and oncological efficacy of multivisceral pancreatic resections across diverse tumor entities. This data will serve as a valuable resource for healthcare professionals and patients in making well-informed clinical decisions. Clinical Trial: PROSPERO Record-ID CRD42023437858
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Copyright
© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it's website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.