Accepted for/Published in: Interactive Journal of Medical Research
Date Submitted: Sep 13, 2023
Date Accepted: Dec 6, 2023
The Effect of Body Temperature Changes on the Course of Treatment in Patients with Pneumonia and Sepsis: Results of an Observational Study
ABSTRACT
Background:
Traditionally, critically ill patients with infection and fever have been cooled in order to decrease metabolic demands.
Objective:
To determine the effect of body temperature on the course of intensive care unit (ICU) treatment of mechanically ventilated patients with pneumonia with positive tracheal aspirates on admission and sepsis.
Methods:
We performed a single-center retrospective study comparing patients with negative tracheal aspirates one week after ICU admission (P-N group), to patients with a different pathogen in tracheal aspirates one week after ICU admission (P-HAP group), and to patients with a persisting pathogen in tracheal aspirates one week after ICU admission (P-P group).
Results:
We observed a significantly higher average temperature in the first 48 hours after ICU admission in patients who survived to hospital discharge (37.2°C (36.6°C, 37.6°C) vs. 36.9°C (35.8°C, 37.4°C), p=0.038). We observed a significantly greater use of paracetamol in the P-N group (1.0±1.1 g vs. 0.4±0.7 g vs. 0.4±0.8 g, p=0.009), a trend towards greater use of active cooling in the first 24 hours after ICU admission in the P-N group (44% vs. 33.3% vs. 32%, p=0.57), and no other significant differences in parameters of ICU treatment between patient groups.
Conclusions:
Our data supports the strategy of temperature tolerance in intubated patients with pneumonia and sepsis. Clinical Trial: /
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