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Accepted for/Published in: JMIR Public Health and Surveillance

Date Submitted: Jul 14, 2023
Date Accepted: Dec 13, 2023

The final, peer-reviewed published version of this preprint can be found here:

Age Differences in the Association of Sleep Duration Trajectory With Cancer Risk and Cancer-Specific Mortality: Prospective Cohort Study

Liu C, Zhang Q, Liu C, Liu T, Song M, Zhang Q, Xie H, Lin S, Chen Y, Zheng X, Shi J, Deng L, Wu S, Hanping S

Age Differences in the Association of Sleep Duration Trajectory With Cancer Risk and Cancer-Specific Mortality: Prospective Cohort Study

JMIR Public Health Surveill 2024;10:e50836

DOI: 10.2196/50836

PMID: 38324354

PMCID: 10882471

Age differences in the association of sleep duration trajectory and cancer risk, cancer-specific mortality: A Prospective Cohort Study

  • Chenan Liu; 
  • Qingsong Zhang; 
  • Chenning Liu; 
  • Tong Liu; 
  • Mengmeng Song; 
  • Qi Zhang; 
  • Hailun Xie; 
  • Shiqi Lin; 
  • Yue Chen; 
  • Xin Zheng; 
  • Jinyu Shi; 
  • Li Deng; 
  • Shouling Wu; 
  • Shi Hanping

ABSTRACT

Background:

Baseline sleep duration is associated with cancer risk, cancer-specific mortality, and all-cause mortality; however, the association between the longitudinal patterns of sleep duration and these risks remains unknown.

Objective:

The present study aimed to elucidate the association between sleep duration trajectory and cancer risk, cancer-specific mortality, and all-cause mortality.

Methods:

The participants recruited in this study were from the Kailuan cohort. The sleep duration of participants was continuously recorded between 2006 and 2010. Latent mixture modeling was used to identify shared sleep duration trajectories. Furthermore, the Cox proportional risk model was used to examine the associations between sleep duration trajectory and cancer risk and cancer-specific and all-cause mortality.

Results:

In total, 53273 participants were included. During a median follow-up of 10.99 years, 2705 participants developed cancers. Furthermore, three sleep duration trajectories were identified: normal-stable (84.18%), median-stable (11.03%), and decreasing low-stable (4.79%). Compared with the normal-stable group, the decreasing low-table group had increased cancer risk, cancer-specific mortality, and all-cause mortality, which were mainly present in young people aged <45 years. Joint analysis revealed that compared with participants who had a stable sleep duration within the normal range and did not snore, those with a shortened sleep duration and snoring had the highest cancer risk.

Conclusions:

Sleep trajectories and quality are closely associated with cancer risk, cancer-specific mortality, and all-cause mortality. However, these associations differ with age and are more pronounced in individuals aged <45 years. Clinical Trial: Kailuan study, ChiCTR–TNRC–11001489. Registered 24 August, 2011, http://www.chictr.org.cn/


 Citation

Please cite as:

Liu C, Zhang Q, Liu C, Liu T, Song M, Zhang Q, Xie H, Lin S, Chen Y, Zheng X, Shi J, Deng L, Wu S, Hanping S

Age Differences in the Association of Sleep Duration Trajectory With Cancer Risk and Cancer-Specific Mortality: Prospective Cohort Study

JMIR Public Health Surveill 2024;10:e50836

DOI: 10.2196/50836

PMID: 38324354

PMCID: 10882471

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