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Accepted for/Published in: JMIR Cancer

Date Submitted: Feb 7, 2023
Date Accepted: Feb 25, 2024

The final, peer-reviewed published version of this preprint can be found here:

Digital Smoking Cessation Intervention for Cancer Survivors: Analysis of Predictors and Moderators of Engagement and Outcome Alongside a Randomized Controlled Trial

Andree R, Mujcic A, den Hollander W, van Laar M, Boon B, Engels R, Blankers M

Digital Smoking Cessation Intervention for Cancer Survivors: Analysis of Predictors and Moderators of Engagement and Outcome Alongside a Randomized Controlled Trial

JMIR Cancer 2024;10:e46303

DOI: 10.2196/46303

PMID: 38901028

PMCID: 11229662

A digital smoking cessation intervention for cancer survivors: Analysis of predictors and moderators of engagement and outcome alongside a randomized controlled trial

  • Rosa Andree; 
  • Ajla Mujcic; 
  • Wouter den Hollander; 
  • Margriet van Laar; 
  • Brigitte Boon; 
  • Rutger Engels; 
  • Matthijs Blankers

ABSTRACT

Background:

Recent studies have shown positive, though small clinical effects of digital smoking cessation (SC) interventions for cancer survivors. However, research on associations between participant characteristics, intervention engagement, and outcomes is limited.

Objective:

The aim of this study was to explore predictors and moderators of engagement and outcome of ‘MyCourse Quit Smoking’(in Dutch: ‘MijnKoers Stoppen met Roken’), a digital minimally guided intervention for cancer survivors.

Methods:

A secondary analysis of data from the randomized controlled trial was performed. The number of cigarettes smoked in the past 7 days at 6-month follow-up was the primary outcome measure. We analyzed interactions between participant characteristics (eleven variables), intervention engagement (three variables), and outcome using Robust Linear (Mixed) Modelling.

Results:

In total, 165 participants were included in our study. Female participants accessed the intervention less often than men (B=-11.12, p=.004). A higher Alcohol Use Disorders Identification Test (AUDIT) score at baseline was associated with a significantly higher number of logins (B=1.10, p<.001) and diary registrations (B=1.29, p<.001). A higher Fagerström Test for Nicotine Dependence (FTND) score at baseline in the intervention group was associated with a significantly larger reduction in tobacco use after 6 months (B=-9.86, p=.002). No other associations and no moderating effects were found.

Conclusions:

Overall, a limited number of associations was found between participant characteristics, engagement and outcome, except for gender, problematic alcohol use, and nicotine dependence. Future studies are needed to shed light on how this knowledge can be used to improve the effects of digital SC programs for cancer survivors. Clinical Trial: The Netherlands Trial Register NTR6011; https://www.trialregister.nl/trial/5434


 Citation

Please cite as:

Andree R, Mujcic A, den Hollander W, van Laar M, Boon B, Engels R, Blankers M

Digital Smoking Cessation Intervention for Cancer Survivors: Analysis of Predictors and Moderators of Engagement and Outcome Alongside a Randomized Controlled Trial

JMIR Cancer 2024;10:e46303

DOI: 10.2196/46303

PMID: 38901028

PMCID: 11229662

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