Accepted for/Published in: JMIR Public Health and Surveillance
Date Submitted: Oct 28, 2022
Date Accepted: Jan 19, 2023
Willingness to vaccinate against herpes zoster and its associated factors across WHO regions: a global systematic review and meta-analysis
ABSTRACT
Background:
A life-course immunization approach would enhance the quality of life across all age groups and improve societal wellbeing. A herpes zoster (HZ) vaccine is a vaccine that reduces the incidence of HZ; HZ vaccines are highly recommended for older adults.
Objective:
The aim of this review was to estimate the HZ vaccine willingness rate and identify factors associated with vaccine uptake willingness across all WHO regions.
Methods:
A global systematic search was performed on PubMed, Web of Science, and The Cochrane Library for all articles related to HZ vaccine published until June 20, 2022. Vaccination willingness rates with 95% confidence intervals (CI) were pooled and reported. The willingness rate and associated factors were analyzed by geographical context. Associated factors were also summarized based on Health Belief Model constructs.
Results:
Of the 26,942 identified records, 13 articles were included, covering 14,066 individuals from eight countries in four WHO regions (Eastern Mediterranean Region, European Region, Region of the Americas, and Western Pacific Region). The pooled vaccination willingness rate was 55.74% (95 % CI: 40.85%, 70.13%). Of adults aged ≥ 50 years, 56.06% were willing to receive the HZ vaccine. After receiving healthcare workers’ (HCWs) recommendations, 75.19% of individuals were willing to get a HZ vaccine; without HCWs’ recommendations, the willingness rate was only 49.39%. The willingness rate was more than 70% in Eastern Mediterranean Region and approximately 55% in Western Pacific Region. The main reasons for unwillingness included low trust in the effectiveness of the HZ vaccine, concerns about safety, low perceptions of disease risk, financial concerns, and being unaware of the HZ vaccine’s availability.
Conclusions:
The willingness rates and associated factors varied across the WHO regions. The practice of life-course immunization should enhance people’s awareness of vaccines and should pay greater attention to the role of HCWs in influencing individual’s willingness to get vaccinated.
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