Accepted for/Published in: JMIR Research Protocols
Date Submitted: Aug 25, 2022
Date Accepted: Dec 14, 2022
Effect of vitamin D on inflammation and dyslipidemia in type 2 diabetes mellitus. A protocol for systematic review and meta-analysis of randomized controlled trials.
ABSTRACT
Background:
Type 2 diabetes mellitus (T2DM) is a chronic disease that contributes to an increasing global burden on the health system. It has a high chance of leading to macrovascular complications and cardiovascular disease. As an inflammatory condition, it would be essential to target inflammatory pathways when developing therapeutic drugs for T2DM.
Objective:
This review is aimed to evaluate the effect of vitamin D on markers of inflammation and dyslipidemia amongst adults with type 2 diabetic patients.
Methods:
A systematic review will seek studies published on EMBASE, PubMed, Web of Science, Science Direct, Google, and Semantic Scholar. This planned, systematic review and meta-analysis will be limited to randomized controlled trials; moreover, the search will include published studies regarding the effects of vitamin D on pro-inflammatory cytokines and features of dyslipidemia. The studies identification and selection will be based on the PICO criteria by two independent reviewers. Additionally, a meta-analysis will only be performed if more than two studies are available and explore the same outcomes, and this will be analyzed using Revman version 5.4. The quality and risk of bias will be assessed following the Cochrane risk of bias tool.
Results:
The review will include randomized controlled trials published from inception until 30th September 2022. The search for relevant studies on different databases has already begun and is expected to be completed by 30th September 2022.
Conclusions:
Although clinical and preclinical studies explored the benefits of vitamin D in diabetes, the results are contradictory. Moreover, the link between inflammation and lipid profile in T2DM is well established; however, diabetic dyslipidemia, diabetic neuropathy, and cardiovascular disease remain the leading causes of diabetes mortality; therefore, further evidence on the impact of vitamin D supplementation is required in the prevention of diabetes-related complications. We will investigate and highlight the effect of vitamin D by analyzing pro-inflammatory cytokines and markers of dyslipidemia in adult patients with T2DM. Clinical Trial: This protocol is registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY), registration number: INPLASY202260022. https://inplasy.com/inplasy-2022-6-0022/
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Copyright
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