Accepted for/Published in: JMIR Research Protocols
Date Submitted: Jul 31, 2022
Date Accepted: Jan 26, 2023
Date Submitted to PubMed: Jan 27, 2023
Inflammatory biomarkers behavior profile among patients following elective degenerative spine surgery and their differences with those coursing with a postoperative spinal infection: Protocol for a Systematic Review
ABSTRACT
Background:
The incidence of postoperative spinal infection range from 0% to 10%, devastatingly affecting the patient prognosis and increasing costs to the healthcare system because of higher morbidity. Current research has focused on serum biomarkers at the early stages of disease, nevertheless, most rely on retrospective cohorts with serum biomarkers studied individually and at different time points.
Objective:
To determine the Inflammatory biomarkers behavior profile among patients following elective degenerative spine surgery and their differences with those coursing with postoperative spinal infection.
Methods:
The proposed systematic review will follow the PRISMA statement. This protocol was registered at PROSPERO on January 19th, 2022, obtaining the following register CRD42022304645 on February 19th, 2022. Figure 1 contains the flow diagram of the methodology.
Results:
No ethical approval will be required, as this review is based on published data and does not involve interaction with human participants. The search for this systematic review commenced in February 2021, and we expect to publish the findings in late 2022.
Conclusions:
In conclusion, the present study will provide the biomarkers' behavior profile for postoperative spinal infection and patients following elective surgery for degenerative spinal diseases from the preoperative period up to 90 days postoperative and provide cutoff values at the day of diagnosis. It will eventually provide clinicians with a better background to establish their diagnosis based on highly trustable information based on cutoff values from this systematic review, which will ultimately impact the patient's physical and mental health, reducing the disease burden. Clinical Trial: Systematic Review registered at PROSPERO with the following ID: CRD42022304645
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