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Accepted for/Published in: JMIR Dermatology

Date Submitted: Jul 7, 2022
Date Accepted: Nov 1, 2023

The final, peer-reviewed published version of this preprint can be found here:

Clinical Efficacy of Nutritional Supplements in Atopic Dermatitis: Systematic Review

Weber I, Woolhiser E, Keime N, Wasvary M, Adelman MJ, Sivesind TE, Dellavalle RP

Clinical Efficacy of Nutritional Supplements in Atopic Dermatitis: Systematic Review

JMIR Dermatol 2023;6:e40857

DOI: 10.2196/40857

PMID: 38019566

PMCID: 10719823

Clinical Efficacy of Nutritional Supplements in Atopic Dermatitis: A Systematic Review

  • Isaac Weber; 
  • Emily Woolhiser; 
  • Noah Keime; 
  • Margaret Wasvary; 
  • Madeline J Adelman; 
  • Torunn E Sivesind; 
  • Robert P Dellavalle

ABSTRACT

Background:

Oral supplements are a growing industry, garnering the attention of patients and medical professionals alike. The marketplace for oral supplements is flooded with a wide range of products offering broad availability and convenience, and supported by a spectrum of customer testimonials. Currently, these supplements are regulated as foods rather than drugs, under the governance of the Food and Drug Administration (FDA). The “food” classification allows these products to become available to customers without proof of meeting the efficacy and safety standards required of pharmaceuticals to enter the marketplace. In line with the surge in popularity of oral supplements, patients are increasingly looking to these medical alternatives as a method to alleviate and potentially treat their atopic dermatitis (AD). To ensure physicians are providing the best care options in the treatment of AD, it is paramount that they understand the utility, safety, and knowledge gaps associated with each type of dietary supplement. Currently, there are research gaps related to the lack of clinical trials investigating dietary supplements, and the fact that existing studies are largely limited to in-vitro or animal-based studies.

Objective:

The objective of this study is to review the literature to objectively identify the effectiveness of oral supplements in the treatment of patients with AD. With the exception of Vitamin B12, magnesium, and apple cider vinegar, this review does not address the efficacy of topical formulations in AD.

Methods:

We performed a PubMed literature review of clinical trials and investigative studies related to atopic dermatitis and a variety of nutritional supplements, supplemented by searches on Google Scholar and ResearchGate.

Results:

We evaluated the evidence associated with vitamin deficiencies and subsequent supplementation of these vitamins, minerals, and other nutritional supplements in patients with atopic dermatitis.

Conclusions:

While dietary supplements continue to be of great public interest, there is minimal/weak to no clinical evidence supporting the use of any of the supplements reviewed as treatments for atopic dermatitis.


 Citation

Please cite as:

Weber I, Woolhiser E, Keime N, Wasvary M, Adelman MJ, Sivesind TE, Dellavalle RP

Clinical Efficacy of Nutritional Supplements in Atopic Dermatitis: Systematic Review

JMIR Dermatol 2023;6:e40857

DOI: 10.2196/40857

PMID: 38019566

PMCID: 10719823

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